Evidence map›Paper›PMID 35338147›Full record

ArticleNPJ Regenerative medicine2022

Patients seeking stem cell therapies-a prospective qualitative analysis from a Regenerative Medicine Consult Service.

Jennifer R Arthurs, Lisa M Nordan, Brian H Hultgren, Michael G Heckman, Dayana Martinez, Zubin Master, Shane A Shapiro

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in NPJ Regenerative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Analysis ofOrthopaedic journal of sports medicine · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Jennifer R ArthursCenter for Regenerative Medicine, Mayo Clinic, Jacksonville, FL, USA.
Lisa M NordanRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Jacksonville, FL, USA.
Brian H HultgrenCenter for Regenerative Medicine, Mayo Clinic, Jacksonville, FL, USA.
Michael G HeckmanDivision of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL, USA.
Dayana MartinezUnited States Navy, Washington, DC, USA.
Zubin Master *Biomedical Ethics Research Program and the Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA. master.zubin@mayo.edu.ORCID http://orcid.org/0000-0002-3462-4546
Shane A Shapiro *Department of Orthopedic Surgery, Mayo Clinic, Jacksonville, FL, USA. shapiro.shane@mayo.edu.ORCID http://orcid.org/0000-0001-5753-0625
WinnMed · USJacksonville College · USMayo Clinic · USMayo Clinic in Arizona · USMayo Clinic in Florida · US

Funding

Designing Effective Health Education for Patients Seeking Unregulated Stem Cell InterventionsR21AG068620 · NIA · MAYO CLINIC ROCHESTER · PI MASTER, ZUBIN · 2021 to 2022
$437k
NIA NIH HHS R21 AG068620
6 · The paper itself

Abstract

Despite patient demand for stem cell therapies (SCTs) for musculoskeletal conditions, there remains limited research on why patients seek SCTs or their sources of information. We employ three questions into a consult intake form: (1) Why are you interested in stem cell treatment for your condition? (2) How did you find out about stem cell treatment for your condition? (3) Have you contacted a stem cell clinic? Responses analyzed, using a qualitative content analysis approach to identify themes reveal many patients seek SCTs to treat pain or delay surgery which may align with some current clinical evidence while other patients express motivations as expected outcomes (e.g., SCTs are better than standard of care or can regenerate tissue) which are not supported by current medical evidence. These differences suggests that patient-centered counseling may help patients by addressing misconceptions and increasing health literacy about expected outcomes of SCTs for treating musculoskeletal conditions.

Identifiers

PMID35338147
PMCPMC8956610
OpenAlexW4221129234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.