Evidence map›Paper›PMID 35338130›Full record

ArticleNature communications2022

Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue.

Haofeng Wang, Yunjie Xiao, Xia Chen, Mengwen Zhang, Guangxin Sun, Feng Wang, Lin Wang, Hanxiao Zhang, Xiaoyu Zhang, Xin Yang and 19 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  5. Review
  6. Review
  7. Article
  8. Reciprocal Host-Evolutionary applications · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Wolbachia: Advancing into a Second Century.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  15. Article
  16. eLife · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 7 institutions in 2 countries.

Haofeng Wang *School of Life Sciences, Tianjin University, Tianjin, China.ORCID http://orcid.org/0000-0001-8175-5621
Yunjie Xiao *School of Life Sciences, Tianjin University, Tianjin, China.
Xia Chen *School of Life Sciences, Tianjin University, Tianjin, China.
Mengwen ZhangDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, USA.ORCID http://orcid.org/0000-0003-2703-211X
Guangxin SunDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, USA.
Feng WangSchool of Life Sciences, Tianjin University, Tianjin, China.
Lin WangShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0003-2482-7638
Hanxiao ZhangSchool of Life Sciences, Tianjin University, Tianjin, China.
Xiaoyu ZhangSchool of Life Sciences, Tianjin University, Tianjin, China.
Xin YangInstitute of Life Sciences, Chongqing Medical University, Chongqing, China.
Wenling LiSchool of Life Sciences, Tianjin University, Tianjin, China.
Yi WeiSchool of Life Sciences, Tianjin University, Tianjin, China.
Deqiang YaoState Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Bing ZhangShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0001-8556-8049
Jun LiShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Wen CuiSchool of Life Sciences, Tianjin University, Tianjin, China.
Fenghua WangSchool of Life Sciences, Tianjin University, Tianjin, China.
Cheng ChenSchool of Life Sciences, Tianjin University, Tianjin, China.
Wei ShenShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0002-3785-2245
Dan SuState Key Lab of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Fang BaiShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Jinhai HuangSchool of Life Sciences, Tianjin University, Tianjin, China.
Sheng YeSchool of Life Sciences, Tianjin University, Tianjin, China.
Lei ZhangSchool of Life Sciences, Tianjin University, Tianjin, China.
Xiaoyun JiState Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing, China.ORCID http://orcid.org/0000-0002-0801-8825
Wei WangInstitute of Life Sciences, Chongqing Medical University, Chongqing, China. wangwei@cqmu.edu.cn.ORCID http://orcid.org/0000-0002-2870-0733
Zefang WangSchool of Life Sciences, Tianjin University, Tianjin, China. zefangwang@tju.edu.cn.ORCID http://orcid.org/0000-0002-0852-6483
Mark HochstrasserDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, USA. mark.hochstrasser@yale.edu.ORCID http://orcid.org/0000-0002-1131-5484
Haitao YangSchool of Life Sciences, Tianjin University, Tianjin, China. yanght@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0002-1875-3268
Tianjin University · CNShanghaiTech University · CNYale University · USChongqing Medical University · CNChina Pharmaceutical University · CNShanghai Jiao Tong University · CNSichuan University · CN

Funding

Mechanisms of Cell Regulation and Manipulation by the Ubiquitin SystemR35GM136325 · NIGMS · YALE UNIVERSITY · PI Mark W Hochstrasser · 2020 to 2026
$6.5M
Degradation of Short Lived Regulatory Protein in YeastR37GM046904 · NIGMS · YALE UNIVERSITY · PI HOCHSTRASSER, MARK W · 2009 to 2018
$3.6M
DEGRADTION OF SHORT-LIVED REGULATORY PROTEINS IN YEASTR01GM046904 · NIGMS · YALE UNIVERSITY · PI HOCHSTRASSER, MARK W · 1992 to 2020
$3.6M
NIGMS NIH HHS R01 GM046904NIGMS NIH HHS R35 GM136325NIGMS NIH HHS R37 GM046904
6 · The paper itself

Abstract

Cytoplasmic incompatibility (CI) results when Wolbachia bacteria-infected male insects mate with uninfected females, leading to embryonic lethality. "Rescue" of viability occurs if the female harbors the same Wolbachia strain. CI is caused by linked pairs of Wolbachia genes called CI factors (CifA and CifB). The co-evolution of CifA-CifB pairs may account in part for the incompatibility patterns documented in insects infected with different Wolbachia strains, but the molecular mechanisms remain elusive. Here, we use X-ray crystallography and AlphaFold to analyze the CI factors from Wolbachia strain wMel called CidA

Indexed as

WolbachiaAnimalsCytoplasmCytosolDrosophila melanogasterFemaleMaleSaccharomyces cerevisiaeSymbiosis

Identifiers

PMID35338130
PMCPMC8956670
OpenAlexW4220901880

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.