ArticleNeurology2022
SEEG Functional Connectivity Measures to Identify Epileptogenic Zones: Stability, Medication Influence, and Recording Condition.
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Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed.
- Network reorganization of anterograde thalamic connectivity during non-periodic patterned deep brain stimulation.iScience · 2026Article
- Directed graph neural networks with partial directed coherence for seizure prediction and epileptogenic network characterization.iScience · 2026Article
- EEG CONNECT: A proposed reporting checklist for EEG-based connectivity studies in clinical epilepsy research.Epilepsia open · 2026Review
- Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography.Brain and behavior · 2026Article
- Antiseizure Networks.Epilepsy currents · 2026Article
- Article
- Utility of Interictal Data in Guiding Pediatric Epilepsy Surgery.Pediatric neurosurgery · 2026Review
- Multi-modal connectome analysis of the stereoelectroencephalography implantation effect: a case report.Clinical neurophysiology practice · 2026Article
- Reduction of interictal epileptic burden by pulsatile corticoid therapy in children with drug-resistant epilepsy-How stable is the effect?Epileptic disorders : international epilepsy journal with videotape · 2025Article
- Quantitative EEG signatures in patients with and without epilepsy development after a first seizure.Epilepsia open · 2025Article
- Preictal connectivity dynamics: Exploring inflow and outflow in iEEG networks.Frontiers in network physiology · 2025Article
- Directionality of neural activity in and out of the seizure onset zone in focal epilepsy.Network neuroscience (Cambridge, Mass.) · 2025Article
- Anti-seizure medication tapering correlates with daytime delta band power reduction in the cortex.Brain communications · 2025Article
- Variability of cortico-cortical evoked potentials in the epileptogenic zone is related to seizure occurrence.Annals of clinical and translational neurology · 2024Article
- The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy.Brain : a journal of neurology · 2024Article
- SEEG4D: a tool for 4D visualization of stereoelectroencephalography data.Frontiers in neuroinformatics · 2024Article
- Imaging and Stereotactic Electroencephalography Functional Networks to Guide Epilepsy Surgery.Neurosurgery clinics of North America · 2024Review
- Predicting radiofrequency thermocoagulation surgical outcomes in refractory focal epilepsy patients using functional coupled neural mass model.Frontiers in neurology · 2024Article
- Article
- Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy.Scientific reports · 2023Article
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Authors and funding
12 authors.
Danika L PauloFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.ORCID 0000-0002-2292-1164
Kristin E WillsFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.ORCID 0000-0002-2652-5679
Graham W JohnsonFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.
Hernan F J GonzalezFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.ORCID 0000-0002-1831-2091
John D RolstonFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.ORCID 0000-0002-8843-5468
Robert P NaftelFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.ORCID 0000-0002-4344-503X
Shilpa B ReddyFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.ORCID 0000-0002-3172-0102
Victoria L MorganFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.ORCID 0000-0001-8263-2324
Hakmook KangFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.ORCID 0000-0001-6876-4021
Shawniqua Williams RobersonFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.ORCID 0000-0003-1331-380X
Saramati NarasimhanFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.ORCID 0000-0002-2965-2200
Dario J EnglotFrom the Departments of Neurological Surgery (D.L.P., K.E.W., R.P.N., V.L.M., S.N., D.J.E.), Radiology and Radiological Sciences (V.L.M., D.J.E.), Biostatistics (V.L.M., S.W.R., D.J.E.), and Neurology (H.K.), Vanderbilt University Medical Center; Vanderbilt University Institute of Imaging Science (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Vanderbilt Institute for Surgery and Engineering (K.E.W., G.W.J., H.F.J.G., V.L.M., S.N., D.J.E.); Department of Biomedical Engineering (G.W.J., H.F.J.G., V.L.M., S.W.R., S.N., D.J.E.), Vanderbilt University, Nashville, TN; Departments of Neurosurgery and Biomedical Engineering (J.D.R.), University of Utah, Salt Lake City; and Department of Pediatrics (S.B.R.), Vanderbilt Children's Hospital, Nashville, TN.ORCID 0000-0001-8373-690X
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MOverall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3MPostdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0MMedical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8MRelating Vigilance to Connectivity and Neurocognition in Temporal Lobe EpilepsyR01NS112252 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGLOT, DARIO J · 2019 to 2023
$3.0MPatient-Specific Modeling and Network Perturbation to Enhance the Predictability of Direct Cortical Stimulation for EpilepsyK23NS114178 · NINDS · UNIVERSITY OF UTAH · PI ROLSTON, JOHN D · 2019 to 2023
$961kMULTIMODAL MAPPING OF SUBCORTICAL AND CORTICAL FUNCTIONAL NETWORK DISTURBANCES IN FOCAL EPILEPSYR00NS097618 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGLOT, DARIO J · 2017 to 2019
$743kMultimodal analysis of interictal and ictal brain connectivity in temporal lobe epilepsyF31NS106735 · NINDS · VANDERBILT UNIVERSITY · PI GONZALEZ, HERNAN FRANCISCO JOSE · 2018 to 2020
$89kNIBIB NIH HHS T32 EB001628NICHD NIH HHS P50 HD103537NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NINDS NIH HHS F31 NS106735NINDS NIH HHS K23 NS114178NINDS NIH HHS R00 NS097618NINDS NIH HHS R01 NS112252
Abstract
BACKGROUND AND
objectivesFunctional connectivity (FC) measures can be used to differentiate epileptogenic zones (EZs) from non-EZs in patients with medically refractory epilepsy. Little work has been done to evaluate the stability of stereo-EEG (SEEG) FC measures over time and their relationship with antiseizure medication (ASM) use, a critical confounder in epilepsy FC studies. We aimed to answer the following questions: Are SEEG FC measures stable over time? Are they influenced by ASMs? Are they affected by patient data collection state?
methodsIn 32 patients with medically refractory focal epilepsy, we collected a single 2-minute prospective SEEG resting-state (awake, eyes closed) data set and consecutive 2-minute retrospective pseudo-rest (awake, eyes open) data sets for days 1-7 postimplantation. ASM dosages were recorded for days 1-7 postimplantation and drug load score (DLS) per day was calculated to standardize and compare across patients. FC was evaluated using directed and nondirected measures. Standard clinical interpretation of ictal SEEG was used to classify brain regions as EZs and non-EZs.
resultsOver 7 days, presumed EZs consistently had higher FC than non-EZs when using between imaginary coherence (ImCoh) and partial directed coherence (PDC) inward strength, without accounting for DLS. These measures were demonstrated to be stable over a short-term period of 3 consecutive days with the same DLS. Between ImCoh FC differences between EZs and non-EZs were reduced with DLS decreases, whereas other measures were not affected by DLS. FC differences between EZs and non-EZs were seen during both resting-state and pseudo-rest conditions; ImCoh values were strongly correlated between the 2 conditions, whereas PDC values were not. DISCUSSION: Inward and nondirected SEEG FC is higher in presumed EZs vs non-EZs and measures are stable over time. However, certain measures may be affected by ASM dose, as between ImCoh differences between EZs and non-EZs are less pronounced with lower doses, and other measures such as PDC are poorly correlated across recording conditions. These findings allow novel insight into how SEEG FC measures may aid surgical localization and how they are influenced by ASMs and other factors.
Indexed as
Drug Resistant EpilepsyEpilepsies, PartialElectroencephalographyHumansProspective StudiesRetrospective StudiesStereotaxic Techniques
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