Evidence map›Paper›PMID 35338053›Full record

ArticleeNeuro

Rapid and Lasting Effects of Activating BDNF-Expressing PVH Neurons on Energy Balance.

Shaw-Wen Wu, Baoji Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  6. A comprehensive review of genetic causes of obesity.World journal of pediatrics : WJP · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shaw-Wen WuDepartment of Neuroscience, the Scripps Research Institute, Jupiter, FL 33458.
Baoji XuDepartment of Neuroscience, the Scripps Research Institute, Jupiter, FL 33458 bxu@scripps.edu.ORCID 0000-0002-2416-6633
Scripps Research Institute · US

Funding

TrkB Neurons in the Control of Body WeightR01DK105954 · NIDDK · UNIVERSITY OF FLORIDA · PI XU, BAOJI · 2016 to 2022
$4.6M
Unraveling the Role of PVH BDNF Neurons in Energy BalanceR01DK103335 · NIDDK · UNIVERSITY OF FLORIDA · PI XU, BAOJI · 2015 to 2022
$4.4M
Regulation of energy expenditure through BDNF neurons in the paraventricular hypothalamusF32DK115099 · NIDDK · SCRIPPS FLORIDA · PI WU, SHAW-WEN · 2018 to 2021
$223k
NIDDK NIH HHS F32 DK115099NIDDK NIH HHS R01 DK103335NIDDK NIH HHS R01 DK105954
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB), are implicit in causing obesity. Mutations that reduce BDNF and TrkB expression are associated with obesity in humans and mice. Recently, it was reported that

Indexed as

Brain-Derived Neurotrophic FactorParaventricular Hypothalamic NucleusAnimalsEnergy MetabolismFemaleHypothalamusMaleMiceNeuronsObesityBdnf protein, mouseBrain-Derived Neurotrophic FactorBDNFenergy expenditurefood intakeneuronal activationparaventricular hypothalamusrespiratory exchange ratio

Identifiers

PMID35338053
PMCPMC8994543
OpenAlexW4221048046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.