ArticleBMC infectious diseases2022
Evaluation of saliva self-collection devices for SARS-CoV-2 diagnostics.
Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Diagnostic accuracy of non-invasive SARS-CoV-2 screening tests: a national prospective analysis.BMC infectious diseases · 2025Trial
- Diagnostic Accuracy of Molecular Testing on Saliva and Oral Swabs for Pulmonary Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Longitudinal analysis of viral and host RNA in blood and saliva during controlled human dengue virus 3 infections.Journal of virology · 2026Article
- Validation of Dried Saliva for Molecular Diagnostics.ACS measurement science au · 2026Article
- A low-cost culture- and DNA extraction-free method for the molecular detection of pneumococcal carriage in saliva.Microbiology spectrum · 2024Article
- Point-of-care isothermal nucleic acid amplification tests: progress and bottlenecks for extraction-free sample collection and preparation.Expert review of molecular diagnostics · 2024Review
- Scalable solutions for global health: the SalivaDirect model.Frontiers in cellular and infection microbiology · 2024Article
- SHEAR saliva collection device augments sample properties for improved analytical performance.Bioengineering & translational medicine · 2023Article
- Saliva as an alternative sample type for detection of pneumococcal carriage in young children.Microbiology (Reading, England) · 2023Article
- The potential of saliva as an accessible and sensitive sample type for the detection of respiratory pathogens and host immunity.The Lancet. Microbe · 2023Review
- Persistence of Pneumococcal Carriage among Older Adults in the Community despite COVID-19 Mitigation Measures.Microbiology spectrum · 2023Article
- Evaluation of an immunochromatography-based rapid antigen test, Inspecter Kowa® SARS-CoV-2, using saliva specimens for the detection of SARS-CoV-2.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2023Article
- Pooled RNA-extraction-free testing of saliva for the detection of SARS-CoV-2.Scientific reports · 2023Article
- Saliva-based SARS-CoV-2 serology using at-home collection kits returned via mail.Scientific reports · 2022Article
- Quantitative serology for SARS-CoV-2 using self-collected saliva and finger-stick blood.Scientific reports · 2022Article
- Quantitative SARS-CoV-2 Viral-Load Curves in Paired Saliva Samples and Nasal Swabs Inform Appropriate Respiratory Sampling Site and Analytical Test Sensitivity Required for Earliest Viral Detection.Journal of clinical microbiology · 2022Article
- A Community Study of SARS-CoV-2 Detection by RT-PCR in Saliva: A Reliable and Effective Method.Viruses · 2022Article
- Sequencing SARS-CoV-2 genomes from saliva.Virus evolution · 2022Article
- Article
- Quantitative SARS-CoV-2 viral-load curves in paired saliva and nasal swabs inform appropriate respiratory sampling site and analytical test sensitivity required for earliest viral detection.medRxiv : the preprint server for health sciences · 2021Article
Corrections and comments
- Update of
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is an urgent need to expand testing for SARS-CoV-2 and other respiratory pathogens as the global community struggles to control the COVID-19 pandemic. Current diagnostic methods can be affected by supply chain bottlenecks and require the assistance of medical professionals, impeding the implementation of large-scale testing. Self-collection of saliva may solve these problems, as it can be completed without specialized training and uses generic materials.
methodsWe observed 30 individuals who self-collected saliva using four different collection devices and analyzed their feedback. Two of these devices, a funnel and bulb pipette, were used to evaluate at-home saliva collection by 60 individuals. SARS-CoV-2-spiked saliva samples were subjected to temperature cycles designed to simulate the conditions the samples might be exposed to during the summer and winter seasons and sensitivity of detection was evaluated.
resultsAll devices enabled the safe, unsupervised self-collection of saliva. The quantity and quality of the samples received were acceptable for SARS-CoV-2 diagnostic testing, as determined by human RNase P detection. There was no significant difference in SARS-CoV-2 nucleocapsid gene (N1) detection between the freshly spiked samples and those incubated with the summer and winter profiles.
conclusionWe demonstrate inexpensive, generic, buffer free collection devices suitable for unsupervised and home saliva self-collection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.