Evidence map›Paper›PMID 35337143›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Efficacy of Adaptogens in Patients with Long COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial.

Irina Karosanidze, Ushangi Kiladze, Nino Kirtadze, Mikhail Giorgadze, Nana Amashukeli, Nino Parulava, Neli Iluridze, Nana Kikabidze, Nana Gudavadze, Lali Gelashvili and 8 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. [Herbal treatment options for post-viral symptoms and long COVID].Wiener medizinische Wochenschrift (1946) · 2026
    Review
  4. Impact of nutrition on long COVID.Sports medicine and health science · 2026
    Review
  5. Systematic Review of Randomized Clinical Trials for the Treatment of Long COVID Syndrome.Journal of community hospital internal medicine perspectives · 2026
    Article
  6. Review
  7. Interventions for Long COVID: A Narrative Review.Journal of general internal medicine · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. The EPMA journal · 2024
    Review
  12. Review
  13. Review
  14. Review
  15. Neuropsychiatric aspects of long COVID: A comprehensive review.Psychiatry and clinical neurosciences · 2023
    Review
  16. Article
  17. Efficacy of Kan JangPharmaceuticals (Basel, Switzerland) · 2022
    Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Irina KarosanidzeNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Ushangi KiladzeNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Nino KirtadzeNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Mikhail GiorgadzeNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Nana AmashukeliNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Nino ParulavaNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Neli IluridzeNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Nana KikabidzeNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Nana GudavadzeNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Lali GelashviliNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Vazha KoberidzeNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Eka GigashviliNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Natela JajanidzeNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Naira LatsabidzeNational Family Medicine Training Centre, 57 M. Tsinamdzghvrishvili Str., Tbilisi 0102, Georgia.
Nato MamageishviliDepartment for History of Medicine and Bioethics, Faculty of Medicine, Tbilisi State Medical University, Vazha-Pshavela Ave. 33, Tbilisi 0162, Georgia.
Ramaz ShengeliaDepartment for History of Medicine and Bioethics, Faculty of Medicine, Tbilisi State Medical University, Vazha-Pshavela Ave. 33, Tbilisi 0162, Georgia.
Areg HovhannisyanInstitute of Fine Organic Chemistry, National Academy of Science, Azatutian ave. 26, Yerevan 375014, Armenia.
Alexander PanossianPhytomed AB, Bofinksvagen 1, 31275 Våxtorp, Sweden.ORCID 0000-0002-8467-4525
Tbilisi State Medical University · GENational Academy of Sciences of Armenia · AM

Funding

Swedish Herbal Institute R&D in Vallberga Nr 2021-2
6 · The paper itself

Abstract

Currently, no effective treatment of comorbid complications or COVID-19 long-haulers during convalescence is known. This randomized, quadruple-blind, placebo-controlled trial aimed to assess the efficacy of adaptogens on the recovery of patients with Long COVID symptoms. One hundred patients with confirmed positive SARS-CoV-2 test, discharged from COVID Hotel isolation, Intensive Care Unit (ICU), or Online Clinics, and who experienced at least three of nine Long COVID symptoms (fatigue, headache, respiratory insufficiency, cognitive performance, mood disorders, loss of smell, taste, and hair, sweatiness, cough, pain in joints, muscles, and chest) in the 30 days before randomization were included in the study of the efficacy of Chisan

Indexed as

adaptogensChisan®/ADAPT-232clinical trialC-reactive proteincreatinineD-dimerIL-6long COVID-19 symptomsphysical performance

Identifiers

PMID35337143
PMCPMC8953947
OpenAlexW4220814303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.