Evidence map›Paper›PMID 35337127›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

α-Glucosidase and Bacterial β-Glucuronidase Inhibitors from the Stems of

Guiwei Rao, Hangfei Yu, Manlai Zhang, Yuchen Cheng, Kun Ran, Jianwei Wang, Bin Wei, Min Li, Weiguang Shan, Zhajun Zhan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Design, synthesis, and biological evaluation of (thio)urea derivatives as potentJournal of enzyme inhibition and medicinal chemistry · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Guiwei RaoCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Hangfei YuCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Manlai ZhangCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Yuchen ChengUniversity of Edinburgh Institute, Zhejiang University, Haining 314400, China.
Kun RanCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Jianwei WangCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Bin WeiCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Min LiZhejiang Huahai Pharmaceutical Co., Ltd., Taizhou 317000, China.
Weiguang ShanCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Zhajun ZhanCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Youmin YingCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Zhejiang University of Technology · CNHuahai Pharmaceutical (China) · CNZhejiang University-University of Edinburgh Institute · CN

Funding

National Key Research & Development Program of China 2020YFF0424461Science and Technology Plan Project of Zhejiang Province LGF20H300010
6 · The paper itself

Abstract

α-Glucosidase (AGS) is a therapeutic target for Type 2 diabetes mellitus (T2DM) that tends to complicate with other diseases. Some medications for the treatment of T2DM complications have the risk of inducing severe adverse reactions such as diarrhea via the metabolism of intestinal bacterial β-glucuronidase (BGUS). The development of new AGS and/or BGUS inhibitors may improve the therapeutic effects of T2DM and its complications. The present work focused on the isolation and characterization of AGS and/or BGUS inhibitors from the medicinal plant

Indexed as

bacterial β-glucuronidasediabetesdrug-induced diarrheaSchisandra sphaerandratriterpenoidsα-glucosidase

Identifiers

PMID35337127
PMCPMC8954508
OpenAlexW4220815910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.