Evidence map›Paper›PMID 35337029›Full record

ReviewViruses2022

Relationship between HIV-1 Gag Multimerization and Membrane Binding.

Christopher Sumner, Akira Ono

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Analysis of Arc/Arg3.1 Oligomerization In Vitro and in Living Cells.International journal of molecular sciences · 2024
    Article
  10. Cooperative Membrane Binding of HIV-1 Matrix Proteins.The journal of physical chemistry. B · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher SumnerDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Akira OnoDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7841-851X
University of Michigan · US

Funding

Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
Mechanisms that determine subcellular sites of HIV-1 assemblyR37AI071727 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Akira Ono · 2017 to 2026
$6.2M
The Molecular Mechanisms Contributing to the Specific Localization of HIV-1 Gag to the Plasma MembraneF31AI134287 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUMNER, CHRISTOPHER AARON · 2018 to 2019
$73k
NIAID NIH HHS F31 AI134287NIAID NIH HHS R37 AI071727NIAID NIH HHS T32 AI007528
6 · The paper itself

Abstract

HIV-1 viral particle assembly occurs specifically at the plasma membrane and is driven primarily by the viral polyprotein Gag. Selective association of Gag with the plasma membrane is a key step in the viral assembly pathway, which is traditionally attributed to the MA domain. MA regulates specific plasma membrane binding through two primary mechanisms including: (1) specific interaction of the MA highly basic region (HBR) with the plasma membrane phospholipid phosphatidylinositol (4,5) bisphosphate [PI(4,5)P

Indexed as

HIV-1Cell Membranegag Gene Products, Human Immunodeficiency VirusMembranesPhosphatidylinositol 4,5-DiphosphateProtein BindingVirus Assemblygag Gene Products, Human Immunodeficiency VirusPhosphatidylinositol 4,5-DiphosphatecapsidGaggenomic RNA bindingHIV-1matrixmembrane bindingmultimerizationnucleocapsidparticle assemblytRNA binding

Identifiers

PMID35337029
PMCPMC8949992
OpenAlexW4220916299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.