ArticleViruses2022
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression.
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In one paragraph
Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- The Reassessed Potential of SARS-CoV-2 Attenuation for COVID-19 Vaccine Development-A Systematic Review.Viruses · 2022Pooled it
- A multimodaliScience · 2026Article
- Development and characterization of mouse-adapted recombinant SARS-CoV-2 expressing reporter genes.Microbiology spectrum · 2026Article
- Article
- SARS-CoV-2 Effects on Respiratory and Neurological Systems: Morphological Findings and Gene Expression in K18-hACE2 Mice Model.Microorganisms · 2026Article
- Live attenuated vaccination protects aged chimeric ACE2 mice from severe SARS-CoV-2 pathogenicity in vivo.PLoS pathogens · 2026Article
- A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms.Signal transduction and targeted therapy · 2026Article
- Transcriptomic insights into the immune dynamics of wild-type mice challenged with SARS-CoV-2 Beta variant.Laboratory animal research · 2026Article
- Neuroinflammatory and transcriptional dynamics during SARS-CoV-2 infection in KRT18-hACE2 mouse brain.Frontiers in immunology · 2026Article
- Immunization with MVA-based vaccines protects K18-hACE2 mice from SARS-CoV-2 infection-associated inflammatory lesions in brains.Frontiers in immunology · 2026Article
- Age-driven shifts in T and NK cell responses amplify inflammation and coagulopathy during viral infection in mice and humans.Frontiers in immunology · 2026Article
- Automated In situ Hybridization for Detection of Viral Pathogens Using RNAscope™.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Comparative systemic pathogenicity and host tropism of ancestral SARS-CoV-2, Delta, and Omicron EG.5 variants in K18-hACE2 mice.Frontiers in immunology · 2026Article
- SARS-CoV-2-International journal of microbiology · 2026Review
- Conserved CD8 T cell vaccines without B cell epitopes drive robust protection against SARS-CoV-2 that is enhanced by intranasal boost.Science advances · 2025Article
- SARS-CoV-2 Infection Influences Wnt/β-Catenin Pathway Components in Astrocytes.Pathogens (Basel, Switzerland) · 2025Article
- Primary leptomeningeal histiocytic lymphoproliferative disorder associated with SARS-CoV-2 brain infection in k18-hACE2 mouse: a case report.Laboratory animal research · 2025Article
- Article
- Comprehensive Analysis of the Impact of Weight Loss Thresholds on Mouse Models of Fatal Viral Infection.Viruses · 2025Article
- SARS-CoV-2 infection of substantia nigra pars compacta induces expression of miR-330-5p at 10 days post-infection.The Journal of general virology · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
21 authors at 7 institutions in 2 countries.
Mariano CarossinoLouisiana Animal Disease Diagnostic Laboratory (LADDL), Louisiana State University, Baton Rouge, LA 61329, USA.ORCID 0000-0003-3864-5915
Devin KenneyNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Aoife K O'ConnellNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Paige MontanaroNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Anna E TsengNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Hans P GertjeNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Kyle A GroszNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Maria EricssonElectron Microscopy Core Facility, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4563-3683
Bertrand R HuberDepartment of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
Susanna A KurnickNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Saravanan SubramaniamDepartment of Medicine, Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-0194-5044
Thomas A KirklandPromega Biosciences, LLC, San Luis Obispo, CA 93401, USA.ORCID 0000-0003-0859-5785
Joel R WalkerPromega Biosciences, LLC, San Luis Obispo, CA 93401, USA.
Kevin P FrancisPerkin Elmer, Hopkinton, MA 01748, USA.
Alexander D KloseInVivo Analytics Inc., New York, NY 10023, USA.
Neal ParagasInVivo Analytics Inc., New York, NY 10023, USA.
Markus BosmannNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.ORCID 0000-0003-2773-1033
Mohsan SaeedNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.
Udeni B R BalasuriyaLouisiana Animal Disease Diagnostic Laboratory (LADDL), Louisiana State University, Baton Rouge, LA 61329, USA.ORCID 0000-0003-0609-678X
Florian DouamNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.ORCID 0000-0002-4791-6767
Nicholas A CrosslandNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA.ORCID 0000-0003-3873-9188
Boston University · USLouisiana State University · USPromega (United States) · USHarvard University · USInVivo Analytics (United States) · USPerkinElmer (United States) · USUniversity of Washington · US
Funding
Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3MDefining the Impact of Per/Polyfluoroalkyl Substance Exposure on Susceptibility to SARS-CoV-2 Infection and DiseaseR21ES032882 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DOUAM, FLORIAN, SCHLEZINGER, JENNIFER J · 2021 to 2022
$445kVectra Polaris Quantitative Pathology Imaging SystemS10OD030269 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CROSSLAND, NICHOLAS ALEXANDER · 2021 to 2021
$402kCharacterization of a human-specific positive regulator of flavivirus infectionK22AI144050 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DOUAM, FLORIAN · 2021 to 2023
$344kVentana Discovery Ultra Research Autostainer: an Ex+ Core serviceS10OD026983 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CROSSLAND, NICHOLAS ALEXANDER · 2019 to 2019
$207kLouisiana State University PG002165NCATS NIH HHS UL1 TR001430NIH HHS 1UL1TR001430NIH HHS K22 AI144050NIH HHS R21 ES032882NIH HHS S10 OD026983NIH HHS S10OD026983NIH HHS S10 OD030269NIH HHS S10OD030269
Abstract
Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model of SARS-CoV-2 infection. We evaluated the clinical and virological dynamics of SARS-CoV-2 using two intranasal doses (10
Indexed as
COVID-19SARS-CoV-2Angiotensin-Converting Enzyme 2Animalsgamma-GlobulinsHumansKeratin-18MelphalanMiceMice, TransgenicViral TropismACE2 protein, humanAngiotensin-Converting Enzyme 2gamma-GlobulinsKeratin-18Melphalancomparative pathologyimmunohistochemistryin situ hybridizationin vivo imagingtranslational animal modeltransmission electron microscopyviral pathogenesis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.