Evidence map›Paper›PMID 35336901›Full record

ArticleViruses2022

Prominent Efficacy of Amantadine against Human Borna Disease Virus Infection In Vitro and In Vivo. Comment on Fink et al. Amantadine Inhibits SARS-CoV-2 In Vitro.

Liv Bode, Detlef E Dietrich, Carsten W Spannhuth, Hanns Ludwig

Open access · goldAbstract readComment
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Liv BodeJoint Senior Scientists, Freelance Bornavirus Workgroup, 14163 Berlin, Germany.ORCID 0000-0002-8935-6198
Detlef E DietrichAmeos Clinic Hildesheim Psychotherapy and Psychiatry, 31135 Hildesheim, Germany.ORCID 0000-0002-1159-6538
Carsten W SpannhuthDepartment of Mental Health, Hannover Medical School, 30625 Hanover, Germany.
Hanns LudwigJoint Senior Scientists, Freelance Bornavirus Workgroup, 14163 Berlin, Germany.
Medizinische Hochschule Hannover · DEUniversity of Hildesheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amantadine (1-amino-adamantane) is a versatile antiviral compound which has been licensed for decades against influenza viruses. During the Corona pandemic, its effect to inhibit SARS-CoV-2 in vitro has been investigated. However, an in vivo oral inapplicability was concluded due to ID

Indexed as

Borna disease virusCOVID-19 Drug TreatmentAmantadineAnimalsAntiviral AgentsHumansSARS-CoV-2AmantadineAntiviral Agentsamantadineantiviralhuman Borna disease virusin vitroin vivo

Identifiers

PMID35336901
PMCPMC8953669
OpenAlexW4214725761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.