Evidence map›Paper›PMID 35336891›Full record

ArticleViruses2022

A Comparative Evaluation of the Estimation of Rabies Virus Antibodies among Free-Roaming, Vaccinated Dogs in Bengaluru, India.

Lekshmi J Das, Shrikrishna Isloor, Alur Kotrappa Santosh, Avinash Bhat, Ramakrishnaiah Sharada, Doddamane Rathnamma, Belamaranahally Muniveerappa Veeregowda, Konanduru Lingappa Phaniraj, Nageshkumar Abhijit Kumar, Abi T Vanak

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Lekshmi J DasKVAFSU-CVA Rabies Diagnostic Laboratory, Department of Microbiology, Veterinary College, KVAFSU, Bengaluru 560024, India.
Shrikrishna IsloorKVAFSU-CVA Rabies Diagnostic Laboratory, Department of Microbiology, Veterinary College, KVAFSU, Bengaluru 560024, India.
Alur Kotrappa SantoshKVAFSU-CVA Rabies Diagnostic Laboratory, Department of Microbiology, Veterinary College, KVAFSU, Bengaluru 560024, India.
Avinash BhatTrouw Nutrition India Pvt. Ltd., Gachibowli, Hyderabad 500032, India.
Ramakrishnaiah SharadaKVAFSU-CVA Rabies Diagnostic Laboratory, Department of Microbiology, Veterinary College, KVAFSU, Bengaluru 560024, India.
Doddamane RathnammaKVAFSU-CVA Rabies Diagnostic Laboratory, Department of Microbiology, Veterinary College, KVAFSU, Bengaluru 560024, India.
Belamaranahally Muniveerappa VeeregowdaOIE Reference Laboratory for Rabies, Department of Microbiology, Veterinary College, KVAFSU, Bengaluru 560024, India.
Konanduru Lingappa PhanirajOIE Reference Laboratory for Rabies, Department of Microbiology, Veterinary College, KVAFSU, Bengaluru 560024, India.
Nageshkumar Abhijit KumarAshoka Trust for Research in Ecology and the Environment, Jakkur, Bengaluru 560064, India.
Abi T VanakAshoka Trust for Research in Ecology and the Environment, Jakkur, Bengaluru 560064, India.ORCID 0000-0003-2435-4260
Karnataka Veterinary Animal and Fisheries Sciences University · INAshoka Trust for Research in Ecology and the Environment · IN

Funding

DBT-Wellcome Trust India Alliance IA/CPHI/15/1/502028
6 · The paper itself

Abstract

Vaccination is the practical solution for the prevention of rabies in dogs. Assessment of the immunogenicity of vaccination includes estimation of specific rabies virus neutralizing antibodies (VNA) in the target species. We undertook a study to estimate the levels of VNA in free-roaming dogs with a history of rabies vaccination in Bengaluru city, India. We compared the rapid fluorescent focus inhibition test (RFFIT) and an in-house quantitative indirect ELISA (iELISA). The study area comprised the jurisdiction of Bruhat Bengaluru Mahanagara Palike (BBMP), the Bengaluru civic body. The BBMP, along with several non-government organizations (NGO), were conducting a trap- neuter- vaccinate- release program for the prevention of dog rabies. Serum samples were collected from 250 free-roaming dogs from representative regions of BBMP, of which 125 had a VNA titre of 0.5 IU or more by the RFFIT. Furthermore, 126 dogs showed percent positivity values (PP values) more than the cut off PP value of 57.1 by the iELISA, accounting for 50.4% of satisfactory post-vaccinal serum conversion. The sensitivity and specificity of the iELISA was 94.4% and 95.2%, respectively. Based on these data, a quantitative iELISA may be a complementary tool for sero-monitoring immune responses of free-ranging animals after rabies vaccination.

Indexed as

Dog DiseasesRabiesRabies VaccinesRabies virusAnimalsAntibodies, BlockingAntibodies, ViralDogsNeutralization TestsVaccinationAntibodies, BlockingAntibodies, ViralRabies VaccinesiELISArabiesserologyvaccinationzoonosis

Identifiers

PMID35336891
PMCPMC8950950
OpenAlexW4214753148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.