Evidence map›Paper›PMID 35336764›Full record

ArticleBiology2022

Free d-Amino Acids in Salivary Gland in Rat.

Masanobu Yoshikawa, Takugi Kan, Kosuke Shirose, Mariko Watanabe, Mitsumasa Matsuda, Kenji Ito, Mitsuru Kawaguchi

Open access · goldAbstract read
In one paragraph

Article in Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Masanobu YoshikawaDepartment of Clinical Pharmacology, School of Medicine, Tokai University, Isehara 259-1193, Japan.
Takugi KanDepartment of Anesthesiology, School of Medicine, Tokai University, Isehara 259-1193, Japan.
Kosuke ShiroseDepartment of Anesthesiology, School of Medicine, Tokai University, Isehara 259-1193, Japan.
Mariko WatanabeDepartment of Anesthesiology, School of Medicine, Tokai University, Isehara 259-1193, Japan.
Mitsumasa MatsudaDepartment of Anesthesiology, School of Medicine, Tokai University, Isehara 259-1193, Japan.
Kenji ItoDepartment of Anesthesiology, School of Medicine, Tokai University, Isehara 259-1193, Japan.
Mitsuru KawaguchiTokyo Dental College, Tokyo 101-0061, Japan.
Tokai University · JPTokyo Dental College · JP

Funding

JPSP KAKENHI grant number 25462932, 18K09514, 18K08830, 18K08831, 18K08869, 19K09337, 21K09004 and 21K08931
6 · The paper itself

Abstract

Free d-amino acids, which are enantiomers of l-amino acids, are found in mammals, including humans, and play an important role in a range of physiological functions in the central nervous system and peripheral tissues. Several d-amino acids have been observed in saliva, but their origin and the enzymes involved in their metabolism and catabolism remain to be clarified. In the present study, large amounts of d-aspartic acid and small amounts of d-serine and d-alanine were detected in all three major salivary glands in rat. No other d-enantiomers were detected. Protein expression of d-amino acid oxidase and d-aspartate oxidase, the enzymes responsible for the oxidative deamination of neutral and dicarboxylic d-amino acids, respectively, were detected in all three types of salivary gland. Furthermore, protein expression of the d-serine metabolic enzyme, serine racemase, in parotid glands amounted to approximately 40% of that observed in the cerebral cortex. The

Indexed as

d-amino acidd-amino acid oxidased-aspartate oxidaseNMDA receptorsalivary glandserine racemase

Identifiers

PMID35336764
PMCPMC8944958
OpenAlexW4214925625

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.