Evidence map›Paper›PMID 35336174›Full record

ArticleMicroorganisms2022

Picornavirus May Be Linked to Parkinson's Disease through Viral Antigen in Dopamine-Containing Neurons of Substantia Nigra.

Bo Niklasson, Lars Lindquist, William Klitz, Sten Fredrikson, Roland Morgell, Reza Mohammadi, Netherlands Brain Bank, Yervand Karapetyan, Elisabet Englund

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Bo NiklassonJordbro Primary Health Care Center, 137 64 Stockholm, Sweden.
Lars LindquistDivision of Infectious Disease, Department of Medicine Huddinge, Karolinska Institutet, 141 86 Stockholm, Sweden.
William KlitzDepartment of Integrative Biology, University of California, Berkeley, CA 94720-3140, USA.
Sten FredriksonDepartment of Neurology, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden.
Roland MorgellJordbro Primary Health Care Center, 137 64 Stockholm, Sweden.
Reza MohammadiJordbro Primary Health Care Center, 137 64 Stockholm, Sweden.ORCID 0000-0003-2294-9316
Netherlands Brain BankNetherlands Brain Bank, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
Yervand KarapetyanIntegrated Biobank of Luxembourg 1, Rue Louis Rech, L-3555 Dudelange, Luxembourg.
Elisabet EnglundDivision of Pathology, Department of Clinical Sciences, University of Lund, 221 85 Lund, Sweden.ORCID 0000-0002-2708-2443
Stockholm Health Care Services · SELund University · SEIntegra (United States) · USKarolinska Institutet · SEKarolinska University Hospital · SENetherlands Institute for Neuroscience · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disease linked with the loss of dopaminergic neurons in the brain region called substantia nigra and caused by unknown pathogenic mechanisms. Two currently recognized prominent features of PD are an inflammatory response manifested by glial reaction and T-cell infiltration, as well as the presence of various toxic mediators derived from activated glial cells. PD or parkinsonism has been described after infection with several different viruses and it has therefore been hypothesized that a viral infection might play a role in the pathogenesis of the disease. We investigated formalin-fixed post-mortem brain tissue from 9 patients with Parkinson's disease and 11 controls for the presence of Ljungan virus (LV) antigen using a polyclonal antibody against the capsid protein of this recently identified picornavirus with neurotropic properties, suspected of being both a human and an animal pathogen. Evidence of viral antigen was found in 7 out of 9 Parkinson's disease cases and in only 1 out of 11 controls (

Indexed as

immunohistochemistryLjungan virusneurodegenerative diseaseParkinson’s diseasepicornavirussubstantia nigra

Identifiers

PMID35336174
PMCPMC8953350
OpenAlexW4220782072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.