Evidence map›Paper›PMID 35336058›Full record

ArticlePharmaceutics2022

Cyclodextrin-Based Nanosponges as Perse Antimicrobial Agents Increase the Activity of Natural Antimicrobial Peptide Nisin.

Yousef Khazaei Monfared, Mohammad Mahmoudian, Gjylije Hoti, Fabrizio Caldera, José Manuel López Nicolás, Parvin Zakeri-Milani, Adrián Matencio, Francesco Trotta

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Yousef Khazaei MonfaredDipartimento Di Chimica, Università di Torino, Via P. Giuria 7, 10125 Torino, Italy.ORCID 0000-0002-1171-8670
Mohammad MahmoudianFaculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 5166414766, Iran.
Gjylije HotiDipartimento Di Chimica, Università di Torino, Via P. Giuria 7, 10125 Torino, Italy.ORCID 0000-0002-0541-980X
Fabrizio CalderaDipartimento Di Chimica, Università di Torino, Via P. Giuria 7, 10125 Torino, Italy.ORCID 0000-0003-2581-0555
José Manuel López NicolásUnidad Docente de Biología, Departamento de Bioquímica y Biología Molecular A, Facultad de Veterinaria, Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, 30100 Murcia, Spain.ORCID 0000-0003-0944-3994
Parvin Zakeri-MilaniLiver and Gastrointestinal Diseases Research Centre, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 5166414766, Iran.
Adrián MatencioDipartimento Di Chimica, Università di Torino, Via P. Giuria 7, 10125 Torino, Italy.ORCID 0000-0001-8203-0673
Francesco TrottaDipartimento Di Chimica, Università di Torino, Via P. Giuria 7, 10125 Torino, Italy.
University of Turin · ITTabriz University of Medical Sciences · IRUniversidad de Murcia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At present, antibiotic resistance is considered a real problem. Therefore, for decades scientists have been looking for novel strategies to treat bacterial infections. Nisin Z, an antimicrobial peptide (AMP), can be considered an option, but its usage is mainly limited by the poor stability and short duration of its antimicrobial activity. In this context, cyclodextrin (CD)-based nanosponges (NSs), synthesized using carbonyldiimidazole (CDI) and pyromellitic dianhydride (PMDA), were chosen for nisin Z loading. To determine the minimum inhibitory of nisin Z loaded on CD-NS formulations, agar well diffusion plates were used. Then, the bactericide concentrations of nisin Z loaded on CD-NS formulations were determined against Gram-positive (

Indexed as

antibacterialcarbonyldiimidazolecyclodextrinEscherichia colinanospongesnisin Zpyromellitic dianhydrideStaphylococcus aureus

Identifiers

PMID35336058
PMCPMC8950107
OpenAlexW4220854230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.