Evidence map›Paper›PMID 35335950›Full record

ReviewPharmaceutics2022

Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations.

Neha Raina, Rakesh Pahwa, Jaydeep Bhattacharya, Alok K Paul, Veeranoot Nissapatorn, Maria de Lourdes Pereira, Sonia M R Oliveira, Karma G Dolma, Mohammed Rahmatullah, Polrat Wilairatana and 1 more

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Review
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  13. Dextran-based stimuli-responsive hydrogels for smart dressings in wound healing.Journal of materials science. Materials in medicine · 2026
    Review
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  19. Harnessing postbiotics for liver health: Emerging perspectives.World journal of gastrointestinal pharmacology and therapeutics · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Neha RainaDepartment of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India.
Rakesh PahwaInstitute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, India.
Jaydeep BhattacharyaSchool of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
Alok K PaulSchool of Pharmacy and Pharmacology, University of Tasmania, Hobart 7001, Australia.ORCID 0000-0002-6090-2407
Veeranoot NissapatornSchool of Allied Health Sciences and World Union for Herbal Drug Discovery (WUHeDD), Walailak University, Nakhon Si Thammarat 80160, Thailand.
Maria de Lourdes PereiraCICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0001-6703-7869
Sonia M R OliveiraCICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-0707-5203
Karma G DolmaDepartment of Microbiology, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok 737102, India.
Mohammed RahmatullahDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Lalmatia, Dhaka 1207, Bangladesh.
Polrat WilairatanaDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0002-2730-7788
Madhu GuptaDepartment of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India.ORCID 0000-0002-8503-0609

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogels are a promising and attractive option as polymeric gel networks, which have immensely fascinated researchers across the globe because of their outstanding characteristics such as elevated swellability, the permeability of oxygen at a high rate, good biocompatibility, easy loading, and drug release. Hydrogels have been extensively used for several purposes in the biomedical sector using versatile polymers of synthetic and natural origin. This review focuses on functional polymeric materials for the fabrication of hydrogels, evaluation of different parameters of biocompatibility and stability, and their application as carriers for drugs delivery, tissue engineering and other therapeutic purposes. The outcome of various studies on the use of hydrogels in different segments and how they have been appropriately altered in numerous ways to attain the desired targeted delivery of therapeutic agents is summarized. Patents and clinical trials conducted on hydrogel-based products, along with scale-up translation, are also mentioned in detail. Finally, the potential of the hydrogel in the biomedical sector is discussed, along with its further possibilities for improvement for the development of sophisticated smart hydrogels with pivotal biomedical functions.

Indexed as

biomedical perspectivesclinical trialscontact lensesdrug deliveryhydrogelstherapeutic interventionstissue engineeringtranslationwound management

Identifiers

PMID35335950
PMCPMC8950534

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.