Evidence map›Paper›PMID 35335904›Full record

ArticlePharmaceutics2022

Electrospun Poly(lactide) Fibers as Carriers for Controlled Release of Biochanin A.

Ivana Gajić, Sanja Stojanović, Ivan Ristić, Snežana Ilić-Stojanović, Branka Pilić, Aleksandra Nešić, Stevo Najman, Ana Dinić, Ljiljana Stanojević, Maja Urošević and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Acceleration of Electrospun PLA Degradation by Addition of Gelatin.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ivana GajićFaculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia.
Sanja StojanovićDepartment of Biology and Human Genetics, Faculty of Medicine, University of Niš, Blvd. Dr Zorana Djindjica 81, 18108 Niš, Serbia.
Ivan RistićFaculty of Technology Novi Sad, University of Novi Sad, 18000 Novi Sad, Serbia.ORCID 0000-0002-4470-4929
Snežana Ilić-StojanovićFaculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia.ORCID 0000-0003-2416-8281
Branka PilićFaculty of Technology Novi Sad, University of Novi Sad, 18000 Novi Sad, Serbia.
Aleksandra NešićFaculty of Technology Novi Sad, University of Novi Sad, 18000 Novi Sad, Serbia.ORCID 0000-0002-3252-4904
Stevo NajmanDepartment of Biology and Human Genetics, Faculty of Medicine, University of Niš, Blvd. Dr Zorana Djindjica 81, 18108 Niš, Serbia.ORCID 0000-0002-2411-9802
Ana DinićFaculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia.ORCID 0000-0003-3119-033X
Ljiljana StanojevićFaculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia.
Maja UroševićFaculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia.ORCID 0000-0002-6949-258X
Vesna NikolićFaculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia.
Ljubiša NikolićFaculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia.
University of Nis · RSUniversity of Novi Sad · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to investigate the possibility of using electrospun polylactide (PLA) fibers as a carrier of the phytoestrogen biochanin A. Polylactide fibers were prepared with different contents of biochanin A by using an electrospinning method at specific process parameters. The obtained electrospun polylactide fibers, as carriers of biochanin A, were characterized by means of different methods. The presented results showed that the mechanical properties of PLA have not changed significantly in the presence of biochanin A. Scanning electron microscopy showed that the fine fiber structure is retained without visible deformations and biochanin A crystals on the surface of the fibres. The analysis by infrared spectroscopy showed that there are no strong interactions between polylactide and biochanin A molecules, which is a good prerequisite for the diffusion release of biochanin A from PLA fibers.The release of biochanin A from PLA fibers in buffer solution pH 7.4 at 37 °C was monitored by applying the HPLC method. The rate and time of the release of biochanin A from PLA fibers is in correlation with the amount of the active ingredient in the matrix of the carrier and follows zero-order kinetics. PLA fibers with biochanin A exhibit concentration-dependent activity on proliferation and migration of L929 fibroblasts in direct culture system in vitro, and proved to be suitable for a potential formulation for use in wound healing.

Indexed as

biochanin Acarriersdrug deliveryelectrospinningphytoestrogenspolylactide

Identifiers

PMID35335904
PMCPMC8951644
OpenAlexW4214721154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.