Evidence map›Paper›PMID 35335881›Full record

ReviewPharmaceutics2022

Nanomedicine as a Promising Tool to Overcome Immune Escape in Breast Cancer.

Alba Navarro-Ocón, Jose L Blaya-Cánovas, Araceli López-Tejada, Isabel Blancas, Rosario M Sánchez-Martín, María J Garrido, Carmen Griñán-Lisón, Jesús Calahorra, Francisca E Cara, Francisco Ruiz-Cabello and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Alba Navarro-OcónGENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain.
Jose L Blaya-CánovasGENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain.ORCID 0000-0002-0986-2841
Araceli López-TejadaGENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain.
Isabel BlancasInstituto de Investigación Biosanitaria (ibs.GRANADA), 18012 Granada, Spain.
Rosario M Sánchez-MartínGENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain.
María J GarridoDepartment of Pharmaceutical Technology and Chemistry, School of Pharmacy & Nutrition, Navarra Institute for Health Research (IdisNA), University of Navarra, 31080 Pamplona, Spain.ORCID 0000-0003-3559-4710
Carmen Griñán-LisónGENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain.ORCID 0000-0003-3853-6292
Jesús CalahorraGENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain.
Francisca E CaraGENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain.ORCID 0000-0002-5488-4994
Francisco Ruiz-CabelloInstituto de Investigación Biosanitaria (ibs.GRANADA), 18012 Granada, Spain.ORCID 0000-0002-2247-3293
Juan A MarchalInstituto de Investigación Biosanitaria (ibs.GRANADA), 18012 Granada, Spain.ORCID 0000-0002-4996-8261
Natalia AptsiauriInstituto de Investigación Biosanitaria (ibs.GRANADA), 18012 Granada, Spain.ORCID 0000-0001-8419-2959
Sergio Granados-PrincipalGENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain.ORCID 0000-0001-8773-9489
Instituto de Investigación Biosanitaria de Granada · ESUniversidad de Granada · ESUniversidad de Navarra · ES

Funding

Asociación Española Contra el Cáncer PRDJA19001BLAYConsejería de Salud y Familias RH-0139-2020Consejería de Transformación Económica, Industria, Conocimiento y Universidades DOC_01686Instituto de Salud Carlos III CP14/00197Instituto de Salud Carlos III CP19/00029Instituto de Salud Carlos III PI15/00336Instituto de Salud Carlos III PI19/01533Ministerio de Ciencia, Innovación y Universidades FPU19/04450
6 · The paper itself

Abstract

Breast cancer is the most common type of malignancy and leading cause of cancer death among women worldwide. Despite the current revolutionary advances in the field of cancer immunotherapy, clinical response in breast cancer is frequently below expectations, in part due to various mechanisms of cancer immune escape that produce tumor variants that are resistant to treatment. Thus, a further understanding of the molecular events underlying immune evasion in breast cancer may guarantee a significant improvement in the clinical success of immunotherapy. Furthermore, nanomedicine provides a promising opportunity to enhance the efficacy of cancer immunotherapy by improving the delivery, retention and release of immunostimulatory agents in targeted cells and tumor tissues. Hence, it can be used to overcome tumor immune escape and increase tumor rejection in numerous malignancies, including breast cancer. In this review, we summarize the current status and emerging trends in nanomedicine-based strategies targeting cancer immune evasion and modulating the immunosuppressive tumor microenvironment, including the inhibition of immunosuppressive cells in the tumor area, the activation of dendritic cells and the stimulation of the specific antitumor T-cell response.

Indexed as

breast cancercancer immunotherapycancer treatmentimmune escapenanomedicine

Identifiers

PMID35335881
PMCPMC8950730
OpenAlexW4214479689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.