Evidence map›Paper›PMID 35335862›Full record

ArticlePharmaceutics2022

Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-βCD Composites Improves Their Antiangiogenic Activity.

Dina Guzmán-Oyarzo, Jacobo Hernández-Montelongo, Carlos Rosas, Pamela Leal, Helga Weber, Marysol Alvear, Luis A Salazar

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dina Guzmán-OyarzoCenter of Molecular Biology and Pharmacogenetics, Department of Basic Sciences, Scientific and Technological Bioresource Nucleus (BIOREN-UFRO), Universidad de La Frontera, Avenida Francisco Salazar 01145, Temuco 4811230, Chile.
Jacobo Hernández-MontelongoBioproducts and Advanced Materials Research Center (BioMA), Faculty of Engineering, Universidad Católica de Temuco, Avenida Rudecindo Ortega 02950, Temuco 4813302, Chile.ORCID 0000-0002-1510-3470
Carlos RosasEscuela de Medicina, Facultad de Medicina y Ciencia, Universidad San Sebastián, General Lagos 1163, Valdivia 5110693, Chile.ORCID 0000-0003-1787-9931
Pamela LealCenter of Excellence in Translational Medicine (CETM) and Scientific and Technological Bioresource Nucleus (BIOREN-UFRO), Universidad de La Frontera, Temuco 4810296, Chile.
Helga WeberCenter of Excellence in Translational Medicine (CETM) and Scientific and Technological Bioresource Nucleus (BIOREN-UFRO), Universidad de La Frontera, Temuco 4810296, Chile.
Marysol AlvearDepartment of Chemical Sciences and Natural Resources, Faculty of Engineering and Sciences, Universidad de La Frontera, Avenida Francisco Salazar 01145, Temuco 4811230, Chile.ORCID 0000-0002-0296-0043
Luis A SalazarCenter of Molecular Biology and Pharmacogenetics, Department of Basic Sciences, Scientific and Technological Bioresource Nucleus (BIOREN-UFRO), Universidad de La Frontera, Avenida Francisco Salazar 01145, Temuco 4811230, Chile.ORCID 0000-0002-5112-6944
Universidad de La Frontera · CLSan Sebastián University · CLUniversidad Católica de Temuco · CL

Funding

Agencia Nacional de Investigación y Desarrollo 1171765
6 · The paper itself

Abstract

Although polyphenols have great pharmacological potential, the main disadvantage is that they have low bioavailability at the desired site. Thus, the use of biocompatible systems for drug delivery is a strategy that is currently gaining great interest. The objective of this study is to evaluate the effect of microencapsulation of caffeic acid and pinocembrin on the antioxidant and antiangiogenic activity of both polyphenols, by the use of nPSi-βCD composite microparticles. For this HUVEC, cells were exposed to H

Indexed as

antiangiogenic activitycaffeic acidcontrolled releaseHUVECsnPSi/βCD microparticlepinocembrinpolyphenols

Identifiers

PMID35335862
PMCPMC8955862
OpenAlexW4214546310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.