Evidence map›Paper›PMID 35335706›Full record

ArticleNanomaterials (Basel, Switzerland)2022

Impact of Fluorinated Ionic Liquids on Human Phenylalanine Hydroxylase-A Potential Drug Delivery System.

Márcia M S Alves, Paula Leandro, Haydyn D T Mertens, Ana B Pereiro, Margarida Archer

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Márcia M S AlvesInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), 2780-157 Oeiras, Portugal.ORCID 0000-0002-2335-400X
Paula LeandroResearch Institute for Medicines (iMed.Ulisboa) and Department of Pharmaceutical Sciences and Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisbon, Portugal.ORCID 0000-0002-2946-9342
Haydyn D T MertensEuropean Molecular Biology Lamboratory (EMBL), Hamburg Unit c/o Deutches Elektronen Synchrotron (DESY), D-22607 Hamburg, Germany.ORCID 0000-0002-5664-744X
Ana B PereiroLAQV, REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (FCT NOVA), 2829-516 Caparica, Portugal.ORCID 0000-0001-7166-6764
Margarida ArcherInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), 2780-157 Oeiras, Portugal.ORCID 0000-0001-8419-5420
Rede de Química e Tecnologia · PTUniversidade Nova de Lisboa · PTUniversity of Lisbon · PT

Funding

Fundação para a Ciência e Tecnologia UID/QUI/50006/2020 (Associate Laboratory for Green Chemistry-LAQV), UIDB/04138/2020 and UIDP/04138/2020 (Research Institute for Medicines; iMed.Ulisboa), UIDB/04612/2020 and UIDP/04612/2020 (MOSTMICRO- ITQB)
6 · The paper itself

Abstract

Phenylketonuria (PKU) is an autosomal recessive disease caused by deficient activity of human phenylalanine hydroxylase (hPAH), which can lead to neurologic impairments in untreated patients. Although some therapies are already available for PKU, these are not without drawbacks. Enzyme-replacement therapy through the delivery of functional hPAH could be a promising strategy. In this work, biophysical methods were used to evaluate the potential of [N

Indexed as

encapsulationfluorinated ionic liquidshuman phenylalanine hydroxylasephenylketonuriasurface-active ionic liquids

Identifiers

PMID35335706
PMCPMC8950220
OpenAlexW4221024414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.