Evidence map›Paper›PMID 35335377›Full record

ArticleMolecules (Basel, Switzerland)2022

Immunomodulatory Efficacy-Mediated Anti-HCV and Anti-HBV Potential of Kefir Grains; Unveiling the In Vitro Antibacterial, Antifungal, and Wound Healing Activities.

Sawsan Abd Ellatif, Elsayed S Abdel Razik, Marwa M Abu-Serie, Ahmed Mahfouz, Abdullah F Shater, Fayez M Saleh, Mohamed M Hassan, Walaa F Alsanie, Abdullah Altalhi, Ghadir E Daigham and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Hypoglycemic Properties ofJournal of fungi (Basel, Switzerland) · 2024
    Article
  3. Review
  4. Article
  5. Kaempferol: A Review of Current Evidence of Its Antiviral Potential.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Sawsan Abd EllatifBioprocess Development Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City for Scientific Research and Technology Applications, New Borg El-Arab, Alexandria 21934, Egypt.
Elsayed S Abdel RazikPlant Protection and Biomolecular Diagnosis Department, Arid Lands Cultivation Research Institute, City for Scientific Research and Technology Applications, New Borg El-Arab, Alexandria 21934, Egypt.
Marwa M Abu-SerieMedical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technology Applications, New Borg El-Arab, Alexandria 21934, Egypt.
Ahmed MahfouzNational Health Service Foundation Trust (NHS), Manchester University, Manchester M14 5RH, UK.
Abdullah F ShaterDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
Fayez M SalehDepartment of Medical Microbiology, Faculty of Medicine, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0001-8417-8874
Mohamed M HassanDepartment of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0003-1612-107X
Walaa F AlsanieDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Abdullah AltalhiDepartment of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Ghadir E DaighamBotany and Microbiology Department, Faculty of Science, Al-Azhar University (Girls Branch), Cairo 11651, Egypt.ORCID 0000-0002-8924-2086
Amira Y MahfouzBotany and Microbiology Department, Faculty of Science, Al-Azhar University (Girls Branch), Cairo 11651, Egypt.
National Health Service · GBTaif University · SACity of Scientific Research and Technological Applications · EGAl-Azhar University · EGUniversity of Tabuk · SA

Funding

Taif University Project number (TURSP-2020/82)Taif University Project number (TURSP-2020/82), Taif University, Taif, Saudia Arabia.
6 · The paper itself

Abstract

The utilization of fermented foods with health-promoting properties is becoming more popular around the world. Consequently, kefir, a fermented milk beverage made from kefir grains, was shown in numerous studies to be a probiotic product providing significant health benefits. Herein, we assessed the antibacterial and antifungal potential of kefir against a variety of pathogenic bacteria and fungi. This study also showed the effectiveness of kefir in healing wounds in human gastric epithelial cells (GES-1) by (80.78%) compared with control (55.75%) within 48 h. The quantitative polymerase chain reaction (qPCR) results of kefir-treated HCV- or HBV- infected cells found that 200 µg/mL of kefir can eliminate 92.36% of HCV and 75.71% of HBV relative to the untreated infected cells, whereas 800 µg/mL (the highest concentration) completely eradicated HCV and HBV. Moreover, the estimated IC

Indexed as

KefirProbioticsAnti-Bacterial AgentsAntifungal AgentsHumansWound HealingAnti-Bacterial AgentsAntifungal Agentsantibacterial activityantifungal activityanti-HBV activityanti-HCV activitygastric epithelial cellsimmunomodulatory efficacykefir grainsprobioticwound healing

Identifiers

PMID35335377
PMCPMC8951848
OpenAlexW4220909504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.