Evidence map›Paper›PMID 35335246›Full record

ArticleMolecules (Basel, Switzerland)2022

Rapid Degradation of SARS-CoV-2 Spike S Protein by A Specific Serine Protease.

Jiankai Liu, Mujie Kan, Lianzhi Zhang, Yuan Yue, Shaohua Wang, Min Hong, Xinyu Hong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiankai LiuBiochemistry Department, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Mujie KanBiochemistry Department, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Lianzhi ZhangBiochemistry Department, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Yuan YueLaboratory of Medical Biology Center, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Shaohua WangInstitute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun 130021, China.
Min HongBiochemistry Department, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Xinyu HongNeuroscience Research Laboratory, Neurosurgery Department, The First Hospital of Jilin University, Jilin University, Changchun 130021, China.
Jilin University · CNJilin Medical University · CN

Funding

Jilin Province Science and Technology Department 202002014 91JC
6 · The paper itself

Abstract

The S protein of SARS-CoV-2 is a crucial structural and functional component for virus entry. Due to the constant mutation of the virus, there are very limited ways to prevent and control COVID-19. This experiment used a macroscopic SDS-PAGE method and proved that the S protein of wild-type SARS-CoV-2 virus, especially the S1 subunit, is very sensitive to alkaline serine protease with acidic pI (ASPNJ), NJ represents

Indexed as

COVID-19Serine ProteasesHumansMembrane GlycoproteinsSARS-CoV-2Viral Envelope ProteinsMembrane GlycoproteinsSerine ProteasesViral Envelope Proteinsalkaline serine protease with an acidic pI (ASPNJ)antiviral agentdegradation of S proteinSARS-CoV-2spike (S) protein

Identifiers

PMID35335246
PMCPMC8954242
OpenAlexW4220834835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.