Evidence map›Paper›PMID 35335188›Full record

ArticleMolecules (Basel, Switzerland)2022

A Water Soluble 2-Phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazole Based Probe: Antimicrobial Activity and Colorimetric/Fluorescence pH Response.

Rosita Diana, Ugo Caruso, Luigi Di Costanzo, Simona Concilio, Stefano Piotto, Lucia Sessa, Barbara Panunzi

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rosita DianaDepartment of Agriculture, University of Naples Federico II, Via Università, 100, 80055 Portici, Italy.
Ugo CarusoDepartment of Chemical Sciences, University of Naples Federico II, Strada Comunale Cinthia, 26, 80126 Napoli, Italy.ORCID 0000-0002-0572-5436
Luigi Di CostanzoDepartment of Agriculture, University of Naples Federico II, Via Università, 100, 80055 Portici, Italy.ORCID 0000-0002-4795-2573
Simona ConcilioDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.ORCID 0000-0002-1461-9301
Stefano PiottoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.ORCID 0000-0002-3102-1918
Lucia SessaDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.ORCID 0000-0002-5343-2777
Barbara PanunziDepartment of Agriculture, University of Naples Federico II, Via Università, 100, 80055 Portici, Italy.ORCID 0000-0001-9253-0794

Funding

Ministry of Education, Universities and Research Piano Lauree Scientifiche "Scienza dei Materiali" 2016-2018
6 · The paper itself

Abstract

The growing demand of responsive tools for biological and biomedical applications pushes towards new low-cost probes easy to synthesize and versatile. Current optical probes are theranostic tools simultaneously responsive to biological parameters/analyte and therapeutically operating. Among the optical methods for pH monitoring, simple small organic molecules including multifunctional probes for simultaneous biological activity being highly desired by scientists and technicians. Here, we present a novel pH-responsive probe with a three-ring heteroaromatic pattern and a flexible cationic chain. The novel molecule shows real-time naked-eye colorimetric and fluorescence response in the slightly acidic pH range besides its excellent solubility both in the organic phase and in water. In addition, the small probe shows significant antibacterial activity, particularly against

Indexed as

Anti-Infective AgentsColorimetryFluorescent DyesHydrogen-Ion ConcentrationOxadiazolesWater1,3,4-oxadiazoleAnti-Infective AgentsFluorescent DyesOxadiazolesWaterantibacterial activitymolecular dynamics studies on probe–cell membrane interactionsnaked-eye colorimetric responsenaked-eye fluorescence responsepH-responsive probe

Identifiers

PMID35335188
PMCPMC8952330

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.