Evidence map›Paper›PMID 35335144›Full record

ArticleMolecules (Basel, Switzerland)2022

Folate Conjugated Polyethylene Glycol Probe for Tumor-Targeted Drug Delivery of 5-Fluorouracil.

Shabnam Sarwar, Muhammad Abdul Qadir, Rima D Alharthy, Mahmood Ahmed, Saghir Ahmad, Michiel Vanmeert, Muhammad Usman Mirza, Abdul Hameed

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  4. Synthesis andResearch in pharmaceutical sciences · 2025
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  6. Recent nanotheranostic approaches in cancer research.Clinical and experimental medicine · 2024
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Shabnam SarwarSchool of Chemistry, University of the Punjab, Lahore 54590, Pakistan.ORCID 0000-0002-1786-5559
Muhammad Abdul QadirSchool of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
Rima D AlharthyChemistry Department, Faculty of Science and Arts, King Abdulaziz University, Rabigh 21911, Saudi Arabia.
Mahmood AhmedDepartment of Chemistry, Division of Science and Technology, University of Education, College Road, Lahore 54770, Pakistan.ORCID 0000-0002-2285-7406
Saghir AhmadSchool of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
Michiel VanmeertMedicinal Chemistry, Department of Pharmaceutical and Pharmacological Sciences, Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.ORCID 0000-0001-5810-4935
Muhammad Usman MirzaMedicinal Chemistry, Department of Pharmaceutical and Pharmacological Sciences, Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.ORCID 0000-0001-9120-2414
Abdul HameedDepartment of Chemistry, University of Sahiwal, Sahiwal 57000, Pakistan.
University of the Punjab · PKRega Institute for Medical Research · BEKing Abdulaziz University · SANamal University · PKUniversity of Education · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A targeted delivery system is primarily intended to carry a potent anticancer drug to specific tumor sites within the bodily tissues. In the present study, a carrier system has been designed using folic acid (FA), bis-amine polyethylene glycol (PEG), and an anticancer drug, 5-fluorouracil (5-FU). FA and PEG were joined via an amide bond, and the resulting FA-PEG-NH

Indexed as

FluorouracilPolyethylene GlycolsAnimalsCell Line, TumorChlorocebus aethiopsFolic AcidHumansMiceMolecular Docking SimulationVero CellsFluorouracilFolic AcidPolyethylene Glycolsfolic acidHeLa cellhepatoma micemolecular dynamics simulationsvector

Identifiers

PMID35335144
PMCPMC8954791
OpenAlexW4221117401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.