Evidence map›Paper›PMID 35335131›Full record

ArticleMolecules (Basel, Switzerland)2022

A Sub-Micromolar MraY

Martin Oliver, Laurent Le Corre, Mélanie Poinsot, Michaël Bosco, Hongwei Wan, Ana Amoroso, Bernard Joris, Ahmed Bouhss, Sandrine Calvet-Vitale, Christine Gravier-Pelletier

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. New MraYAntibiotics (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martin OliverUniversité de Paris, Faculté des Sciences, UMR CNRS 8601, LCBPT, F-75006 Paris, France.ORCID 0000-0002-3602-0228
Laurent Le CorreUniversité de Paris, Faculté des Sciences, UMR CNRS 8601, LCBPT, F-75006 Paris, France.ORCID 0000-0002-0136-8072
Mélanie PoinsotUniversité de Paris, Faculté des Sciences, UMR CNRS 8601, LCBPT, F-75006 Paris, France.
Michaël BoscoUniversité de Paris, Faculté des Sciences, UMR CNRS 8601, LCBPT, F-75006 Paris, France.ORCID 0000-0002-6872-3999
Hongwei WanUniversité de Paris, Faculté des Sciences, UMR CNRS 8601, LCBPT, F-75006 Paris, France.ORCID 0000-0002-6906-3996
Ana AmorosoUnité de Physiologie et Génétique Bactériennes, Centre d'Ingénierie des Protéines, Département des Sciences de la Vie, Université de Liège, Sart Tilman, B4000 Liège, Belgium.
Bernard JorisUnité de Physiologie et Génétique Bactériennes, Centre d'Ingénierie des Protéines, Département des Sciences de la Vie, Université de Liège, Sart Tilman, B4000 Liège, Belgium.
Ahmed BouhssUniversité Paris-Saclay, INSERM U1204, Univ Evry, Structure-Activité des Biomolécules Normales et Pathologiques (SABNP), F-91025 Evry-Courcouronnes, France.
Sandrine Calvet-VitaleUniversité de Paris, Faculté des Sciences, UMR CNRS 8601, LCBPT, F-75006 Paris, France.ORCID 0000-0003-2135-2083
Christine Gravier-PelletierUniversité de Paris, Faculté des Sciences, UMR CNRS 8601, LCBPT, F-75006 Paris, France.ORCID 0000-0002-5946-9722

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New inhibitors of the bacterial tranferase MraY are described. Their structure is based on an aminoribosyl uridine scaffold, which is known to be important for the biological activity of natural MraY inhibitors. A decyl alkyl chain was introduced onto this scaffold through various linkers. The synthesized compounds were tested against the MraY

Indexed as

DiamideTransferasesBacterial ProteinsMolecular Dynamics SimulationTransferases (Other Substituted Phosphate Groups)UridineBacterial ProteinsDiamideTransferasesTransferases (Other Substituted Phosphate Groups)Uridinecarbacaprazamycin analogsinhibition testsinhibitors synthesismolecular docking studiesMraY transferase

Identifiers

PMID35335131
PMCPMC8954382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.