Evidence map›Paper›PMID 35335056›Full record

ReviewVaccines2022

Roles of the Tol/Pal System in Bacterial Pathogenesis and Its Application to Antibacterial Therapy.

Hidetada Hirakawa, Kazutomo Suzue, Haruyoshi Tomita

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Frontiers in microbiology · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. A Bird's-Eye View of the Pathophysiologic Role of the Human Urobiota in Health and Disease: Can We Modulate It?Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Review
  15. Chlorogenic Acid InhibitsMicroorganisms · 2023
    Article
  16. Article
  17. Proteome Exploration ofMicrobiology spectrum · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hidetada HirakawaDepartment of Bacteriology, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Gunma, Japan.
Kazutomo SuzueDepartment of Infectious Diseases and Host Defense, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Gunma, Japan.ORCID 0000-0002-8959-5746
Haruyoshi TomitaDepartment of Bacteriology, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Gunma, Japan.
Gunma University · JP

Funding

Japan Agency for Medical Research and Development 19fk0108061h0502Japan Society for the Promotion of Science 19K07533Japan Society for the Promotion of Science 21K11669
6 · The paper itself

Abstract

The Tol/Pal system (also written as "The Tol-Pal system") is a set of protein complexes produced by most Gram-negative bacteria. It comprises the inner membrane-associated and the outer membrane-anchored subunits composed of the TolA, TolQ, and TolR proteins and the TolB and Pal proteins, respectively. Although the Tol/Pal system was first defined as bacterial proteins involved in colicin uptake of

Indexed as

antimicrobial chemotherapybacterial pathogenesisdrug resistanceGram-negative bacteriaouter membrane proteinvaccinevirulence

Identifiers

PMID35335056
PMCPMC8953051
OpenAlexW4220916595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.