Evidence map›Paper›PMID 35335037›Full record

ReviewVaccines2022

Nasal Nanovaccines for SARS-CoV-2 to Address COVID-19.

Jialu Huang, Yubo Ding, Jingwei Yao, Minghui Zhang, Yu Zhang, Zhuoyi Xie, Jianhong Zuo

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Characterization of Spray-Dried Powders Using a Coated Alberta Idealized Nasal Inlet.Journal of aerosol medicine and pulmonary drug delivery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jialu HuangThe Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Yubo DingNanhua Hospital Affiliated to University of South China, Hengyang Medical School, University of South China, Hengyang 421002, China.
Jingwei YaoNanhua Hospital Affiliated to University of South China, Hengyang Medical School, University of South China, Hengyang 421002, China.
Minghui ZhangThe Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Yu ZhangThe Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Zhuoyi XieThe Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Jianhong ZuoThe Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
University of South China · CN

Funding

the Key Research Program of Hunan Health Committee 20201909the Program of Hengyang science and Technology Bureau 2017-1, 2020-67
6 · The paper itself

Abstract

COVID-19 is still prevalent around the globe. Although some SARS-CoV-2 vaccines have been distributed to the population, the shortcomings of vaccines and the continuous emergence of SARS-CoV-2 mutant virus strains are a cause for concern. Thus, it is vital to continue to improve vaccines and vaccine delivery methods. One option is nasal vaccination, which is more convenient than injections and does not require a syringe. Additionally, stronger mucosal immunity is produced under nasal vaccination. The easy accessibility of the intranasal route is more advantageous than injection in the context of the COVID-19 pandemic. Nanoparticles have been proven to be suitable delivery vehicles and adjuvants, and different NPs have different advantages. The shortcomings of the SARS-CoV-2 vaccine may be compensated by selecting or modifying different nanoparticles. It travels along the digestive tract to the intestine, where it is presented by GALT, tissue-resident immune cells, and gastrointestinal lymph nodes. Nasal nanovaccines are easy to use, safe, multifunctional, and can be distributed quickly, demonstrating strong prospects as a vaccination method for SARS-CoV-2, SARS-CoV-2 variants, or SARS-CoV-n.

Indexed as

COVID-19nanovaccinenasal vaccination

Identifiers

PMID35335037
PMCPMC8952855
OpenAlexW4221137154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.