Evidence map›Paper›PMID 35335022›Full record

ReviewVaccines2022

Protective Efficacy of BCG Vaccine against

Davit Orujyan, William Narinyan, Subhapradha Rangarajan, Patrida Rangchaikul, Chaya Prasad, Beatrice Saviola, Vishwanath Venketaraman

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07094711 (Safety, Immunogenicity, and Efficacy of Therapeutic Mycobacterium Bovis BCG in Patients With Mycobacterium Avium Complex Lung Disease), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07094711 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Safety, Immunogenicity, and Efficacy of Therapeutic Mycobacterium Bovis BCG in Patients With Mycobacterium Avium Complex Lung Disease (BOOST)

TypeinterventionalSponsorUniversity of VirginiaRan2026 to 2028Enrolled48ConditionsMycobacterium Avium-intracellulare Infection, Mycobacterium Infections, NontuberculousArmsMycobacterium bovis Bacillus Calmette Guerin (BCG) vaccine, preservative-free saline
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Pathogenesis of Cutaneous Mycobacterial Infections-International journal of molecular sciences · 2025
    Review
  6. Review
  7. Frontiers in immunology · 2025
    Article
  8. Article
  9. Antibiotics (Basel, Switzerland) · 2024
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Microorganisms · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Davit OrujyanCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0001-6184-3624
William NarinyanCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0002-0120-4289
Subhapradha RangarajanCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Patrida RangchaikulCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Chaya PrasadCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Beatrice SaviolaCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Vishwanath VenketaramanCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0002-2586-1160
Western University of Health Sciences · US

Funding

Glutathione depletion in the CNS and its effects on Mtb infectionR15HL143545 · NHLBI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI VENKETARAMAN, VISHWANATH · 2019 to 2024
$852k
NHLBI NIH HHS R15 HL143545
6 · The paper itself

Abstract

The genus mycobacterium includes several species that are known to cause infections in humans. The microorganisms are classified into tuberculous and non-tuberculous based on their morphological characteristics, defined by the dynamic relationship between the host defenses and the infectious agent. Non-tuberculous mycobacteria (NTM) include all the species of mycobacterium other than the ones that cause tuberculosis (TB). The group of NTM contains almost 200 different species and they are found in soil, water, animals-both domestic and wild-milk and food products, and from plumbed water resources such as sewers and showerhead sprays. A systematic review of Medline between 1946 and 2014 showed an 81% decline in TB incidence rates with a simultaneous 94% increase in infections caused by NTM. Prevalence of infections due to NTM has increased relative to infections caused by TB owing to the stringent prevention and control programs in Western countries such as the USA and Canada. While the spread of typical mycobacterial infections such as TB and leprosy involves human contact, NTM seem to spread easily from the environment without the risk of acquiring from a human contact except in the case of

Indexed as

BCGM. abscessusM. aviumM. lepraeM. marinumM. ulceransnon-tuberculous mycobacteria

Identifiers

PMID35335022
PMCPMC8952781
OpenAlexW4214863252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.