Evidence map›Paper›PMID 35334994›Full record

ArticleVaccines2022

Susac Syndrome Following COVID-19 Vaccination: A Case Report.

Po-Jui Chen, Yi-Sheng Chang, Chen-Chee Lim, Yu-Kuei Lee

Open access · goldAbstract readCase Reports
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Ophthalmic manifestations in patients recovered from COVID-19 in Mexico.Archivos de la Sociedad Espanola de Oftalmologia · 2023
    Observational
  5. [Ophthalmic manifestations in patients recovered from COVID-19 in Mexico].Archivos de la Sociedad Espanola de Oftalmologia · 2023
    Article
  6. Review
  7. Retinal artery/vein occlusion complicating SARS-CoV-2 vaccinations.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Po-Jui ChenDepartment of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Yi-Sheng ChangDepartment of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Chen-Chee LimDepartment of Ophthalmology, Tainan Hospital, Ministry of Health and Welfare, Tainan 700, Taiwan.
Yu-Kuei LeeDepartment of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.ORCID 0000-0002-7200-1067
National Cheng Kung University Hospital · TWChest Hospital, Ministry of Health and Welfare · TW

Funding

National Cheng Kung University Hospital NCKUH-11005001
6 · The paper itself

Abstract

Due to the COVID-19 pandemic, numerous vaccines have been developed for the disease. However, with large-scale vaccination has come the gradual emergence of immunological phenomena caused by these new vaccines. Herein, we report a 48-year-old female with a sudden onset of inferior visual field defects in the left eye following her first dose of the ChAdOx1 vaccine. Dilated fundus examination combined with optical coherence tomography and fluorescein angiography confirmed the diagnosis of branch retinal artery occlusion. Within 4 weeks following vaccination, symptoms associated with hearing impairment developed, and magnetic resonance imaging revealed leptomeningeal enhancement. The diagnosis of Susac syndrome (SS) was confirmed. The development of SS may be caused by endotheliopathy resulting from the molecular mimicry of the ChAdOx1 vaccine. Clinicians should be aware of the symptoms of SS, which may develop after COVID-19 vaccination. Further experimental surveillance and case-control studies are required to confirm this relationship.

Indexed as

adenoviral vector vaccinecase reportCOVID-19 vaccineSusac syndrome

Identifiers

PMID35334994
PMCPMC8954499
OpenAlexW4214664260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.