ArticleNutrients2022
Obesity-Related Brain Cholinergic System Impairment in High-Fat-Diet-Fed Rats.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Neural mechanisms linking Western diet consumption and cognitive impairment: a role for the vagus nerve.Clinical science (London, England : 1979) · 2026Review
- A lifespan staging model of basal forebrain cholinergic vulnerability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Co-Exposure to Food-Grade and Nano-TiOToxics · 2026Article
- Associations of Maternal Pre-Pregnancy BMI With Frontostriatal Connectivity in Young Children.Pediatric obesity · 2026Article
- High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review).International journal of molecular medicine · 2026Review
- High-fat diet-induced anorexia in rats: involving orosensory deficits, gastrointestinal dysfunction, intestinal taste receptor downregulation and dopamine signaling dysregulation.European journal of medical research · 2025Article
- Acipimox as a potential antioxidant and neuromodulator mitigates high fat diet induced cognitive dysfunction.Scientific reports · 2025Article
- High-Fat-Diet-Induced Kidney Injury in Rats: The Role of Tart Cherry Supplementation.Antioxidants (Basel, Switzerland) · 2025Article
- Review
- Association between weight-adjusted waist circumference index and risk of cognitive decline in Chinese hypertensive patients: a case-control study.Frontiers in public health · 2025Article
- Obesity as Inducer of Cognitive Function Decline via Dysbiosis of Gut Microbiota in Rats.Brain sciences · 2024Article
- Childhood Obesity, Hypothalamic Inflammation, and the Onset of Puberty: A Narrative Review.Nutrients · 2024Review
- Neural correlates of obesity across the lifespan.Communications biology · 2024Article
- Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling.Brain, behavior, and immunity · 2024Article
- Mendelian Randomization Analysis Identifies Inverse Causal Relationship between External Eating and Metabolic Phenotypes.Nutrients · 2024Article
- High caloric intake improves neuronal metabolism and functional hyperemia in a rat model of early AD pathology.Theranostics · 2024Article
- Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat model.Open life sciences · 2024Article
- Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling.bioRxiv : the preprint server for biology · 2023Article
- Type D Personality and Health Behaviors in People Living with Obesity.International journal of environmental research and public health · 2022Article
- Anti-Inflammatory and Antioxidant Properties of Tart Cherry Consumption in the Heart of Obese Rats.Biology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
A link between obesity and cerebral health is receiving growing recognition. Here, we investigate in the frontal cortex and hippocampus the potential involvement of cholinergic markers in brain alterations previously reported in rats with obesity induced by diet (DIO) after long-term exposure (17 weeks) to a high-fat diet (HFD) in comparison with animals fed with a standard diet (CHOW). The obesity developed after 5 weeks of HFD. Bodyweight, systolic blood pressure, glycemia, and insulin levels were increased in DIO rats compared to the CHOW group. Measurements of malondialdehyde (MDA) provided lipid peroxidation in HFD-fed rats. Western blot and immunohistochemical techniques were performed. Our results showed a higher expression of choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) in obese rats but not the VAChT expression in the frontal cortex after 17 weeks of HFD. Furthermore, the acetylcholinesterase (AChE) enzyme was downregulated in HFD both in the frontal cortex and hippocampus. In the brain regions analyzed, it was reported a modulation of certain cholinergic receptors expressed pre- and post-synaptically (alpha7 nicotinic receptor and muscarinic receptor subtype 1). Collectively, these findings point out precise changes of cholinergic markers that can be targeted to prevent cerebral injuries related to obesity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.