Evidence map›Paper›PMID 35334879›Full record

ArticleNutrients2022

Qianqian Wang, Min Guo, Yang Liu, Mengshu Xu, Liuting Shi, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05795946 (Effects of a Whole Food Based Nutritional Formulation on Trimethylamine N-oxide and Cardiometabolic Endpoints in Healthy Adults.), which is not on this map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05795946 naterminatednot on this mapstarted 2023, after this paper: background citation

Effects of a Whole Food Based Nutritional Formulation on Trimethylamine N-oxide and Cardiometabolic Endpoints in Healthy Adults.

TypeinterventionalSponsorStandard Process Inc.Ran2023 to 2024Enrolled14ConditionsNutrition, HealthyArmsWhole food-based B and D vitamins
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Effect ofInternational journal of medical sciences · 2026
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  14. Frontiers in cardiovascular medicine · 2026
    Article
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  19. Nutrients · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Qianqian WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Min GuoState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Yang LiuKLATASDS-MOE, School of Statistics, East China Normal University, Shanghai 200062, China.
Mengshu XuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Liuting ShiState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Xiu LiState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Jianxin ZhaoState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Hao ZhangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0002-9192-4684
Gang WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0003-2007-2143
Wei ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Jiangnan University · CNEast China Normal University · CN

Funding

Fundamental Research Funds for the Central Universities JUSRP22006, JUSRP51501National Natural Science Foundation of China 31972052, 32021005, 31820103010Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Prov-ince no number
6 · The paper itself

Abstract

Atherosclerosis is the main cause of myocardial infarction and stroke, and the morbidity and mortality rates of cardiovascular disease are among the highest of any disease worldwide. Excessive plasma trimethylamine-N-oxide (TMAO), an intestinal metabolite, promotes the development of atherosclerosis. Therefore, effective measures for reducing plasma TMAO production can contribute to preventing atherosclerosis. Probiotics are living microorganisms that are beneficial to the human body, and some of them can attenuate plasma TMAO production. To explore the effects of probiotic supplementation on plasma TMAO in choline-fed mice, we intragastrically administered eight strains of

Indexed as

Bifidobacterium breveBifidobacterium longumGastrointestinal MicrobiomeAnimalsCholineMethylaminesMiceMice, Inbred C57BLCholineMethylaminestrimethyloxamineatherosclerosischolinegut microbiotaprobioticstrimethylaminetrimethylamine N-oxide

Identifiers

PMID35334879
PMCPMC8950610
OpenAlexW4220686162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.