Evidence map›Paper›PMID 35334878›Full record

ArticleNutrients2022

Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV.

Mónica Manzano, Alba Talavera-Rodríguez, Elena Moreno, Nadia Madrid, María José Gosalbes, Raquel Ron, Fernando Dronda, José A Pérez-Molina, Val F Lanza, Jorge Díaz and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 20 citations in OpenAlex.

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  19. Protective effect ofBioscience of microbiota, food and health · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Mónica ManzanoDepartment of Nutrition and Food Science, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0003-1697-1461
Alba Talavera-RodríguezDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, 28034 Madrid, Spain.
Elena MorenoDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, 28034 Madrid, Spain.ORCID 0000-0002-2301-4558
Nadia MadridDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, 28034 Madrid, Spain.
María José GosalbesFISABIO-Salud Pública, 46020 Valencia, Spain.
Raquel RonDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, 28034 Madrid, Spain.
Fernando DrondaDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, 28034 Madrid, Spain.ORCID 0000-0002-0443-5816
José A Pérez-MolinaDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, 28034 Madrid, Spain.
Val F LanzaBioinformatics Unit, Hospital Universitario Ramón y Cajal and IRYCIS, 28034 Madrid, Spain.
Jorge DíazDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, 28034 Madrid, Spain.
Santiago MorenoDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, 28034 Madrid, Spain.ORCID 0000-0002-2843-1094
Beatriz NaviaDepartment of Nutrition and Food Science, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Sergio Serrano-VillarDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, 28034 Madrid, Spain.ORCID 0000-0002-5447-3554
Instituto de Salud Carlos III · ESUniversidad Complutense de Madrid · ESInstituto Ramón y Cajal de Investigación Sanitaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation.

Indexed as

Gastrointestinal MicrobiomeHIV InfectionsSexual and Gender MinoritiesBiomarkersDietHomosexuality, MaleHumansMaleBiomarkersD-dimerdietErysipelotrichaceaeHIVinflammatory biomarkersLachnospiramicrobiotaTNF

Identifiers

PMID35334878
PMCPMC8954190
OpenAlexW4220906084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.