Evidence map›Paper›PMID 35334810›Full record

ReviewNutrients2022

The Role of Diet and Interventions on Multiple Sclerosis: A Review.

Panagiotis Stoiloudis, Evangelia Kesidou, Christos Bakirtzis, Styliani-Aggeliki Sintila, Natalia Konstantinidou, Marina Boziki, Nikolaos Grigoriadis

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06715436 (The Effects of Ketogenic Diet Therapy Versus the Mediterranean Diet on Quality of Life in a Group of Patients With Multiple Sclerosis - the KETOMED-MS Study), which is not on this map. Cited by 94 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 9 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06715436 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effects of Ketogenic Diet Therapy Versus the Mediterranean Diet on Quality of Life in a Group of Patients With Multiple Sclerosis - the KETOMED-MS Study

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2024 to 2025Enrolled111ConditionsMultiple Sclerosis, Relapsing-RemittingArmsMediterranean Diet, Ketogenic Diet, Control group
3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 9 syntheses or guidelines pooled it, 135 citations in OpenAlex.

  1. Pooled it
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  10. Trial
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  12. Review
  13. Article
  14. Article
  15. Associations between lifestyle factors and 2.5-year clinical outcomes differ by time since multiple sclerosis diagnosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  16. Review
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Panagiotis Stoiloudis2nd Department of Neurology, AHEPA Hospital, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.ORCID 0000-0002-2380-5018
Evangelia Kesidou2nd Department of Neurology, AHEPA Hospital, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Christos Bakirtzis2nd Department of Neurology, AHEPA Hospital, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.ORCID 0000-0002-4737-3707
Styliani-Aggeliki Sintila2nd Department of Neurology, AHEPA Hospital, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Natalia Konstantinidou2nd Department of Neurology, AHEPA Hospital, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Marina Boziki2nd Department of Neurology, AHEPA Hospital, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.ORCID 0000-0002-6601-5163
Nikolaos Grigoriadis2nd Department of Neurology, AHEPA Hospital, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.ORCID 0000-0002-4278-3301
Aristotle University of Thessaloniki · GR

Funding

Genesis Pharma ESO.0423006
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by inflammation and neurodegeneration. The most prominent clinical features include visual loss and sensorimotor symptoms and mainly affects those of young age. Some of the factors affecting its pathogenesis are genetic and/or environmental including viruses, smoking, obesity, and nutrition. Current research provides evidence that diet may influence MS onset, course, and quality of life of the patients. In this review, we address the role of nutrition on MS pathogenesis as well as dietary interventions that show promising beneficial results with respect to MS activity and progression. Investigation with large prospective clinical studies is required in order to thoroughly evaluate the role of diet in MS.

Indexed as

Multiple SclerosisQuality of LifeCentral Nervous SystemDietHumansProspective Studiesdietgut–brain axisgut microbiotamultiple sclerosisnutrition

Identifiers

PMID35334810
PMCPMC8955724
OpenAlexW4220827491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.