Evidence map›Paper›PMID 35334586›Full record

ArticleMedicina (Kaunas, Lithuania)2022

Hemorrhagic Colitis Caused by Everolimus in a Patient with Nonfunctional Pancreatic Neuroendocrine Neoplasms: A Case Report.

Noriyuki Arakawa, Atsushi Irisawa, Kazuyuki Ishida, Takuya Tsunoda, Yoshiko Yamaguchi, Akane Yamabe, Makoto Eizuka, Shunzo Tokioka, Hiroto Wakabayashi

Open access · goldAbstract readCase Reports
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Noriyuki ArakawaDepartment of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan.ORCID 0000-0002-9521-0451
Atsushi IrisawaDepartment of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Japan.ORCID 0000-0002-2271-2717
Kazuyuki IshidaDepartment of Diagnostic Pathology, Dokkyo Medical University, Mibu 321-0293, Japan.ORCID 0000-0002-2804-4588
Takuya TsunodaDepartment of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan.
Yoshiko YamaguchiDepartment of Diagnostic Pathology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan.
Akane YamabeDepartment of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Japan.
Makoto EizukaDepartment of Internal Medicine, Division of Gastroenterology, Iwate Medical University, Morioka 020-0023, Japan.
Shunzo TokiokaDepartment of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan.
Hiroto WakabayashiDepartment of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan.
Ijinkai Takeda General Hospital · JPDokkyo Medical University · JPIwate Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 60-year-old woman was diagnosed with nonfunctional pancreatic neuroendocrine neoplasm with multiple liver metastases and was administered everolimus. Due to persistent epigastric pain and diarrhea, a colonoscopy was performed on the 14th day after the start of everolimus administration, which revealed small bleeding ulcers in the ileocecal region, transverse colon, and rectum. These adverse effects were attributed to the everolimus; it was immediately discontinued, and the patient's clinical symptoms and imaging findings improved. We concurred that the administration of calcium channel blockers resulted in the inhibition of everolimus metabolism and the disease onset. The everolimus was discontinued. There was no subsequent recurrence of hemorrhagic colitis.

Indexed as

Antineoplastic AgentsColitisPancreatic NeoplasmsEverolimusFemaleGastrointestinal HemorrhageHumansMiddle AgedAntineoplastic AgentsEverolimuseverolimushemorrhagic colitisnonfunctional pancreatic neuroendocrine neoplasms

Identifiers

PMID35334586
PMCPMC8951418
OpenAlexW4220657112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.