Evidence map›Paper›PMID 35334347›Full record

ArticleAtherosclerosis2022

Joint associations of peripheral artery disease and accelerometry-based physical activity with mortality: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Yumin Gao, Simin Hua, Yejin Mok, Maya Salameh, Qibin Qi, Guochong Chen, Jessica Williams-Nguyen, Mollie Pester, Olga Garcia-Bedoya, Daniela Sotres-Alvarez and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Yumin GaoJohns Hopkins University, Baltimore, MD, USA.
Simin HuaAlbert Einstein College of Medicine, The Bronx, NY, USA.
Yejin MokJohns Hopkins University, Baltimore, MD, USA.
Maya SalamehJohns Hopkins University, Baltimore, MD, USA.
Qibin QiAlbert Einstein College of Medicine, The Bronx, NY, USA.
Guochong ChenAlbert Einstein College of Medicine, The Bronx, NY, USA.
Jessica Williams-NguyenFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Mollie PesterUniversity of Miami, Coral Gables, FL, USA.
Olga Garcia-BedoyaUniversity of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Daniela Sotres-AlvarezUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Martha L DaviglusUniversity of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Yasmin Mossavar-RahmaniAlbert Einstein College of Medicine, The Bronx, NY, USA.
Jennifer A SchrackJohns Hopkins University, Baltimore, MD, USA.
Matthew AllisonUniversity of California San Diego, San Diego, CA, USA.
Robert KaplanAlbert Einstein College of Medicine, The Bronx, NY, USA; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kunihiro MatsushitaJohns Hopkins University, Baltimore, MD, USA. Electronic address: kuni.matsushita@jhu.edu.
Albert Einstein College of Medicine · USJohns Hopkins University · USUniversity of Illinois Chicago · USFred Hutch Cancer Center · USUniversity of California San Diego · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · US

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JILL CRANDALL · 2015 to 2026
$27.7M
CTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patientsUL1TR002556 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, KIM, MIMI Y · 2018 to 2022
$26.7M
PASOS: Peripheral Artery Disease Study of SOL. An ancillary study of the Hispanic Community Health Study/Study of LatinosR01HL146132 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KAPLAN, ROBERT C, MATSUSHITA, KUNIHIRO · 2019 to 2022
$8.4M
Cardiometabolic Outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS)R01HL136266 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KAPLAN, ROBERT C, MOSSAVAR-RAHMANI, YASMIN · 2017 to 2020
$3.1M
Thalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6M
GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7M
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NCATS NIH HHS UL1 TR002556NHGRI NIH HHS HHSN268201300003CNHLBI NIH HHS HHSN268201300001CNHLBI NIH HHS HHSN268201300003INHLBI NIH HHS HHSN268201300004CNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL136266NHLBI NIH HHS R01 HL146132NIDDK NIH HHS P30 DK020541
6 · The paper itself

Abstract

BACKGROUND AND

aimsPeripheral artery disease (PAD) and lower levels of physical activity are both associated with higher mortality. Yet, their joint prognostic impact has not been systematically examined, especially in Hispanics/Latinos, and with objective measures. We aimed to examine the joint associations of PAD and physical activity with mortality in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

methodsWe studied 7,620 Hispanic/Latino adults aged 45-74 years at baseline (2008-2011) who underwent assessment of PAD with ankle-brachial index (ABI) and physical activity with hip-worn accelerometry. We calculated four physical activity measures: sedentary time, light activity, moderate/vigorous activity, and total activity counts. We quantified the relationship between ABI and mortality overall, and by tertiles of activity measures in restricted cubic splines, using multivariable Cox models accounting for sampling weights. We also assessed cross-categories of ABI and activity measures with mortality.

resultsDuring a median follow up of 7.1 years, 314 participants died. We observed a U-shaped association of ABI with mortality overall (e.g., hazard ratio 1.80 [95%CI 1.20-2.80] at ABI 0.7 vs 1.2). This U-shaped association was generally consistent after stratifying by activity measures, but an elevated mortality risk for higher ABI was not evident in the most active tertile based on sedentary time, time in light activity, and total activity counts. In the cross-category analysis of ABI and physical activity, the highest mortality risk was consistently seen in abnormal ABI (≤0.9 or >1.4) plus the least active tertile (e.g., HR 5.61 [3.31-9.51] for light activity), compared to referent ABI (0.9-1.4) plus the other more active two tertiles, with no interactions between ABI and activity measure.

conclusionsAbnormal ABI and lower accelerometry-based physical activity were independently and jointly associated with mortality in Hispanics, suggesting the importance of simultaneously evaluating leg vascular condition and physical activity.

Indexed as

Peripheral Arterial DiseasePublic HealthAccelerometryAnkle Brachial IndexExerciseHispanic or LatinoHumansRisk FactorsAccelerometerCardiovascular diseasePeripheral artery diseasePhysical activityStudy of Latinos

Identifiers

PMID35334347
PMCPMC9014557
OpenAlexW4220998194

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.