Evidence map›Paper›PMID 35334230›Full record

ArticleCurrent biology : CB2022

Cullin-5 mutants reveal collective sensing of the nucleocytoplasmic ratio in Drosophila embryogenesis.

Luke Hayden, Anna Chao, Victoria E Deneke, Massimo Vergassola, Alberto Puliafito, Stefano Di Talia

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cul2 Is Essential for theInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Collective effects of cell cleavage dynamics.Frontiers in cell and developmental biology · 2024
    Review
  7. Review
  8. Two-fluid dynamics and micron-thin boundary layers shape cytoplasmic flows in earlyProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Luke HaydenDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Anna ChaoDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Victoria E DenekeDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Massimo VergassolaLaboratoire de physique de l'École Normale Supérieure, CNRS, PSL Research University, Sorbonne Université, Paris, France; Department of Physics, University of California, San Diego, La Jolla, CA, USA.
Alberto PuliafitoCandiolo Cancer Institute, FPO-IRCCS, Laboratory of Cell Migration, 10060 Candiolo, Italy; Department of Oncology, Università di Torino, 10060 Candiolo, Italy.
Stefano Di TaliaDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: stefano.ditalia@duke.edu.
Duke University · USCandiolo Cancer Institute · ITCentre National de la Recherche Scientifique · FR

Funding

Time-keeping mechanisms of embryonic cell cyclesR01GM122936 · NIGMS · DUKE UNIVERSITY · PI DI TALIA, STEFANO · 2017 to 2023
$2.0M
Mechanisms and developmental functions of cytoplasmic flows in early embryogenesisR01GM136763 · NIGMS · DUKE UNIVERSITY · PI DI TALIA, STEFANO · 2021 to 2023
$1.1M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM122936NIGMS NIH HHS R01 GM136763
6 · The paper itself

Abstract

In most metazoans, early embryonic development is characterized by rapid division cycles that pause before gastrulation at the midblastula transition (MBT).

Indexed as

Cullin ProteinsDrosophilaActomyosinAnimalsCell CycleEmbryonic DevelopmentEmbryo, NonmammalianActomyosinCullin Proteinsactomyosin contractilityCdk1cell cyclecullin-5midblastula transitionnuclear positioningnuclear-to-cytoplasmic ratioSrc

Identifiers

PMID35334230
PMCPMC9090985
OpenAlexW4220969132

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.