Evidence map›Paper›PMID 35334216›Full record

ArticleStem cell reports2022

Transcriptional profiling of β-2M

Maelle Givelet, Virginie Firlej, Bruno Lassalle, Anne Sophie Gille, Clementine Lapoujade, Isabelle Holtzman, Amandine Jarysta, Farahd Haghighirad, Florent Dumont, Sébastien Jacques and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Maelle GiveletUniversité de Paris and Université Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches et Radiations, iRCM/IBFJ, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France; Institut Cochin, INSERM U1016, Département de Génétique, Développement et Cancer, Équipe Génomique Epigénétique et Physiopathologie de la Reproduction, 75014 Paris, France.
Virginie FirlejUniversité de Paris and Université Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches et Radiations, iRCM/IBFJ, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France; Institut Cochin, INSERM U1016, Département de Génétique, Développement et Cancer, Équipe Génomique Epigénétique et Physiopathologie de la Reproduction, 75014 Paris, France.
Bruno LassalleUniversité de Paris and Université Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches et Radiations, iRCM/IBFJ, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France.
Anne Sophie GilleUniversité de Paris and Université Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches et Radiations, iRCM/IBFJ, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France; Institut Cochin, INSERM U1016, Département de Génétique, Développement et Cancer, Équipe Génomique Epigénétique et Physiopathologie de la Reproduction, 75014 Paris, France.
Clementine LapoujadeUniversité de Paris and Université Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches et Radiations, iRCM/IBFJ, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France.
Isabelle HoltzmanInstitut Cochin, INSERM U1016, Département de Génétique, Développement et Cancer, Équipe Génomique Epigénétique et Physiopathologie de la Reproduction, 75014 Paris, France.
Amandine JarystaUniversité de Paris and Université Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches et Radiations, iRCM/IBFJ, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France.
Farahd HaghighiradUFR Médecine Paris Centre-Université de Paris, 15 rue de l'école de Médecine, 75006 Paris, France.
Florent DumontUniversité Paris Saclay, UMS IPSIT, 92296 Châtenay-Malabry, France.
Sébastien JacquesUniversité de Paris, Institut Cochin, INSERM, U1016, CNRS UMR8104, Plateforme Séquençage et Génomique, 75014 Paris, France.
Franck LetourneurUniversité de Paris, Institut Cochin, INSERM, U1016, CNRS UMR8104, Plateforme Séquençage et Génomique, 75014 Paris, France.
Françoise PflumioUniversité de Paris and Université Paris-Saclay, INSERM, CEA, UMR Stabilité Génétique Cellules Souches et Radiations, iRCM/IBFJ, LSHL, 92265 Fontenay-aux-Roses, France.
Isabelle AllemandUniversité de Paris and Université Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches et Radiations, iRCM/IBFJ, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France.
Catherine PatratUFR Médecine Paris Centre-Université de Paris, 15 rue de l'école de Médecine, 75006 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Centre, CHU Cochin, Histologie-Embryologie-Biologie de la Reproduction, 75014 Paris, France.
Nicolas ThiounnDepartment of urology and transplant surgery, Hôpital européen Georges-Pompidou, AP-HP, Université de Paris, 20 rue Leblanc, 75015 Paris, France.
Jean Philippe WolfUFR Médecine Paris Centre-Université de Paris, 15 rue de l'école de Médecine, 75006 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Centre, CHU Cochin, Histologie-Embryologie-Biologie de la Reproduction, 75014 Paris, France.
Lydia RiouUniversité de Paris and Université Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches et Radiations, iRCM/IBFJ, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France.
Virginie Barraud-LangeUFR Médecine Paris Centre-Université de Paris, 15 rue de l'école de Médecine, 75006 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Centre, CHU Cochin, Histologie-Embryologie-Biologie de la Reproduction, 75014 Paris, France.
Pierre FouchetUniversité de Paris and Université Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches et Radiations, iRCM/IBFJ, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France. Electronic address: pierre.fouchet@cea.fr.
Université Paris-Saclay · FRUniversité Paris Cité · FRAssistance Publique – Hôpitaux de Paris · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInstitut Cochin · FRCEA Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male infertility is responsible for approximately half of all cases of reproductive issues. Spermatogenesis originates in a small pool of spermatogonial stem cells (SSCs), which are of interest for therapy of infertility but remain not well defined in humans. Using multiparametric analysis of the side population (SP) phenotype and the α-6 integrin, THY1, and β-2 microglobulin cell markers, we identified a population of human primitive undifferentiated spermatogonia with the phenotype β-2 microglobulin (β-2M)

Indexed as

Adult Germline Stem CellsSpermatogenesisAnimalsGene Expression ProfilingHumansMaleMiceSpermatogoniaStem CellsTestisTranscription FactorsTranscription Factorshumanspermatogenesisstem celltranscriptome

Identifiers

PMID35334216
PMCPMC9023810
OpenAlexW4220712188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.