Evidence map›Paper›PMID 35334150›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2022

Quantitative norovirus viral load is not affected by home storage of stool.

Michael G Ison, Ming Tan, Amna Daud, Pengwei Huang, Jason Xi Jiang

Abstract read
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Quantitative norovirus viral load is not affected by home storage of stool.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael G IsonDivisions of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-3347-9671
Ming TanDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Amna DaudDivisions of Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Pengwei HuangDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Jason Xi JiangDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
NCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1TR001422NIAID NIH HHS HHSN272201600016CNIAID NIH HHS HHSN273301600016C
6 · The paper itself

Abstract

In preparation of a clinical trial of norovirus treatment, there were concerns raised by FDA about risk of self-storage of stool from patients infected with norovirus affecting quantitative assessments of norovirus RNA. Specifically, most home freezers are frost-free and may expose the samples to multiple rounds of freeze-thaw. Stool samples collected by the study team were stored at different lengths in a frost-free freezer and at -80°C. Quantitative PCRs of norovirus were performed on all samples using the same assay. By all measures, there was no significant change in measured viral load with home storage.

Indexed as

Caliciviridae InfectionsNorovirusFecesHumansReal-Time Polymerase Chain ReactionRNA, ViralViral LoadRNA, Viralfrost-free refrigeratorhome storagenorovirusquantitative viral loadstability

Identifiers

PMID35334150
PMCPMC9233081

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.