Evidence map›Paper›PMID 35334139›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Korbin H J West, Curran G Gahan, Patricia R Kierski, Diego F Calderon, Ke Zhao, Charles J Czuprynski, Jonathan F McAnulty, David M Lynn, Helen E Blackwell

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. EngineeredBiochemistry · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Structural characteristics, functions, and counteracting strategies of biofilms inComputational and structural biotechnology journal · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Angewandte Chemie (International ed. in English) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Korbin H J WestDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, WI 53706, USA.
Curran G GahanDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Dr., Madison, WI 53706, USA.
Patricia R KierskiDepartment of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Dr., Madison, WI 53706, USA.
Diego F CalderonDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Dr., Madison, WI 53706, USA.
Ke ZhaoDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, WI 53706, USA.
Charles J CzuprynskiDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Dr., Madison, WI 53706, USA.
Jonathan F McAnultyDepartment of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Dr., Madison, WI 53706, USA.
David M LynnDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, WI 53706, USA.
Helen E BlackwellDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, WI 53706, USA.ORCID http://orcid.org/0000-0003-4261-8194
University of Wisconsin–Madison · US

Funding

Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
Materials that Block Quorum Sensing and Attenuate Bacterial Infection in Skin WoundsR21AI135745 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 2018 to 2019
$408k
National Science Foundation DMR-1720415NIAID NIH HHS R21 AI135745NIGMS NIH HHS T32 GM008505NIH HHS R21 AI135745NIH HHS T32 GM008505
6 · The paper itself

Abstract

A synthetic peptide was found to block cell-to-cell signalling, or quorum sensing, in bacteria and be highly bioavailable in mouse tissue. The controlled release of this agent from degradable polymeric microparticles strongly inhibited skin infection in a wound model at levels that far surpassed the potency of the peptide when delivered conventionally.

Indexed as

Anti-InfectiveCell-Cell SignallingControlled ReleasePeptidesQuorum Sensing

Identifiers

PMID35334139
PMCPMC9322450
OpenAlexW4220924109

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.