ArticleJournal of the Association for Research in Otolaryngology : JARO2022
Simulation of ITD-Dependent Single-Neuron Responses Under Electrical Stimulation and with Amplitude-Modulated Acoustic Stimuli.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Exploring the relationship between larmor-frequency electrical conductivity, diffusivity, and tissue volume in the aging brain.Quantitative imaging in medicine and surgery · 2025Article
- Pulse timing dominates binaural hearing with cochlear implants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Rate dependent neural responses of interaural-time-difference cues in fine-structure and envelope.PeerJ · 2024Article
- Simulation of ITD-Dependent Single-Neuron Responses Under Electrical Stimulation and with Amplitude-Modulated Acoustic Stimuli.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Temporal hyper-precision of brainstem neurons alters spatial sensitivity of binaural auditory processing with cochlear implants.Frontiers in neuroscience · 2022Article
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Authors and funding
3 authors.
Funding
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Abstract
Interaural time difference (ITD) sensitivity with cochlear implant stimulation is remarkably similar to envelope ITD sensitivity using conventional acoustic stimulation. This holds true for human perception, as well as for neural response rates recorded in the inferior colliculus of several mammalian species. We hypothesize that robust excitatory-inhibitory (EI) interaction is the dominant mechanism. Therefore, we connected the same single EI-model neuron to either a model of the normal acoustic auditory periphery or to a model of the electrically stimulated auditory nerve. The model captured most features of the experimentally obtained response properties with electric stimulation, such as the shape of rate-ITD functions, the dependence on stimulation level, and the pulse rate or modulation-frequency dependence. Rate-ITD functions with high-rate, amplitude-modulated electric stimuli were very similar to their acoustic counterparts. Responses obtained with unmodulated electric pulse trains most resembled acoustic filtered clicks. The fairly rapid decline of ITD sensitivity at rates above 300 pulses or cycles per second is correctly simulated by the 3.1-ms time constant of the inhibitory post-synaptic conductance. As the model accounts for these basic properties, it is expected to help in understanding and quantifying the binaural hearing abilities with electric stimulation when integrated in bigger simulation frameworks.
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