ArticleCellular and molecular life sciences : CMLS2022
Inflammation and neutrophil extracellular traps in cerebral cavernous malformation.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 34 citations in OpenAlex.
- Cerebral cavernous malformations: epidemiology, molecular pathogenesis, diagnosis and therapy.Molecular biomedicine · 2026Review
- Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CXCL13⁺ CD4⁺ T cells are associated with B-cell recruitment and lesion progression in cerebral cavernous malformations.Journal of neuroinflammation · 2026Article
- Colchicine as an Adjunctive Therapy to Improve Ischemic Stroke Reperfusion Outcomes in Mice.CNS neuroscience & therapeutics · 2026Article
- Evolution of neutrophil extracellular traps in the pathology of stroke.Neural regeneration research · 2026Article
- A 'Tangled Web' in the CNS: unraveling neutrophil extracellular traps in neurological disorders.Molecular neurodegeneration · 2026Review
- Tumor-like proliferation of CCM3 knockout endothelial cells: insights from semaxinib treatment and transcriptome profiling of co-cultures.Acta neuropathologica communications · 2026Article
- Leukocytosis at Presentation Is an Independent Predictor for Hemorrhage in Cerebral Cavernoma.Diagnostics (Basel, Switzerland) · 2026Article
- MEKK3 bridges gut-brain communication and cerebral cavernous malformation pathogenesis.Cell death discovery · 2026Review
- The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation.Brain and behavior · 2026Review
- Integration of artificial intelligence and high-content screening enabled identification of drugs for long-term treatment of cerebral cavernous malformation disease.bioRxiv : the preprint server for biology · 2025Article
- Restoring brain barriers: an innovative approach for treating neurological disorders.Fluids and barriers of the CNS · 2025Review
- Persistent Activation of Endothelial Cells is Linked to Thrombosis and Inflammation in Cerebral Cavernous Malformation Disease.bioRxiv : the preprint server for biology · 2025Article
- Neutrophil extracellular traps as therapeutics target in vascular aging.Frontiers in immunology · 2025Review
- DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.Frontiers in immunology · 2025Article
- Single-cell transcriptome profiling reveals dynamic cell populations and immune infiltration in cerebral cavernous malformation.Frontiers in immunology · 2025Article
- Cerebral cavernous malformation with prolonged postoperative paralysis due to perilesional inflammation: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Neutrophil extracellular traps worsen clotting and neuroinflammation in cavernomas.Nature cardiovascular research · 2024Article
- Review
- Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation.Nature cardiovascular research · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
21 authors at 5 institutions in 4 countries.
Anthony C Y YauDepartment of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv. 20, 751 85, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-1570-7813
Maria Ascencion GlobischDepartment of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv. 20, 751 85, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-2251-9810
Favour Chinyere OnyeogaziriDepartment of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv. 20, 751 85, Uppsala, Sweden.
Lei L ConzeDepartment of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv. 20, 751 85, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-8698-3842
Ross SmithDepartment of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv. 20, 751 85, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-4239-3204
Suvi JauhiainenDepartment of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv. 20, 751 85, Uppsala, Sweden.
Monica CoradaVascular Biology Unit, The FIRC Institute of Molecular Oncology Foundation, Milan, Italy.ORCID http://orcid.org/0000-0001-8220-0871
Fabrizio OrsenigoVascular Biology Unit, The FIRC Institute of Molecular Oncology Foundation, Milan, Italy.ORCID http://orcid.org/0000-0001-9135-8478
Hua HuangDepartment of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv. 20, 751 85, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-0914-6562
Melanie HerreDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Anna-Karin OlssonDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-5438-7293
Matteo MalinvernoVascular Biology Unit, The FIRC Institute of Molecular Oncology Foundation, Milan, Italy.ORCID http://orcid.org/0000-0001-8242-7937
Veronica SundellDepartment of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv. 20, 751 85, Uppsala, Sweden.
Behnam Rezai JahromiDepartment of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0003-3937-2816
Mika NiemeläDepartment of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0003-1526-0684
Aki LaaksoDepartment of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0002-5312-4926
Cecilia GarlandaDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.ORCID http://orcid.org/0000-0002-1510-7703
Alberto MantovaniDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.ORCID http://orcid.org/0000-0001-5578-236X
Maria Grazia LampugnaniVascular Biology Unit, The FIRC Institute of Molecular Oncology Foundation, Milan, Italy.ORCID http://orcid.org/0000-0002-4802-7064
Elisabetta DejanaDepartment of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv. 20, 751 85, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-0007-0426
Peetra U MagnussonDepartment of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv. 20, 751 85, Uppsala, Sweden. Peetra.magnusson@igp.uu.se.ORCID http://orcid.org/0000-0003-1142-854X
Uppsala University · SEIFOM · ITUniversity of Helsinki · FIHumanitas University · ITMario Negri Institute for Pharmacological Research · IT
Funding
H2020 European Research Council 74292Vetenskapsrådet 2013-9279
Abstract
Cerebral Cavernous Malformation (CCM) is a brain vascular disease with various neurological symptoms. In this study, we describe the inflammatory profile in CCM and show for the first time the formation of neutrophil extracellular traps (NETs) in rodents and humans with CCM. Through RNA-seq analysis of cerebellum endothelial cells from wild-type mice and mice with an endothelial cell-specific ablation of the Ccm3 gene (Ccm3
Indexed as
Extracellular TrapsHemangioma, Cavernous, Central Nervous SystemAnimalsApoptosis Regulatory ProteinsEndothelial CellsHumansInflammationMembrane ProteinsMiceApoptosis Regulatory ProteinsMembrane ProteinsCerebral cavernous malformationsEndothelial cellsInflammationNeutrophil extracellular traps
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.