Evidence map›Paper›PMID 35333973›Full record

ReviewPediatric nephrology (Berlin, Germany)2022

Clinicopathologic features of non-lupus membranous nephropathy in a pediatric population.

Paul Miller, Li Lei, Vivek Charu, John Higgins, Megan Troxell, Neeraja Kambham

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Observational
  2. Semaphorin 3B-Membranous Nephropathy in Adults.Kidney international reports · 2026
    Article
  3. EXT2 transition in adolescent membranous nephritis.Pediatric nephrology (Berlin, Germany) · 2026
    Article
  4. Review
  5. Questions and Caveats in Antigen-Defined Membranous Nephropathy.Journal of the American Society of Nephrology : JASN · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. The Many Faces of NELL1 MN.Clinical kidney journal · 2023
    Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Paul Miller *Department of Pathology, Stanford University, H2110, 300 Pasteur Drive, Stanford, CA, 94305, USA. ppmiller@stanford.edu.
Li Lei *Department of Pathology, Stanford University, H2110, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Vivek CharuDepartment of Pathology, Stanford University, H2110, 300 Pasteur Drive, Stanford, CA, 94305, USA.
John HigginsDepartment of Pathology, Stanford University, H2110, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Megan TroxellDepartment of Pathology, Stanford University, H2110, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Neeraja KambhamDepartment of Pathology, Stanford University, H2110, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Stanford University · USUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMembranous nephropathy is an uncommon cause of nephrotic syndrome in pediatrics.

methodsWe reviewed our kidney biopsy records for patients ≤ 20 years of age with membranous nephropathy without evidence of systemic lupus erythematosus within 6 months of biopsy (January 1995-September 2020). Staining for PLA2R, NELL1, THSD7A, SEMA3B, EXT2 (3 biopsies), and IgG-subclass were performed.

resultsSixteen children (≤ 12 years) and 25 adolescents (13-20 years) were identified. Four children and 15 adolescents showed autoantigen positivity: PLA2R+/SEMA3B- (13), SEMA3B+/PLA2R+ (2), SEMA3B+/PLA2R- (1), NELL1 (1), EXT2+ (2), and THSD7A (0). Co-morbidities associated with PLA2R positivity included IPEX syndrome, active hepatitis B, Von Hippel Lindau syndrome, solitary kidney, type 1 diabetes, hyperuricemia, pregnancy (1), obesity (3), type II diabetes, H. pylori, viral prodrome, and nephrolithiasis. The SEMA3B+/PLA2R- adolescent was pregnant, the NELL1+ adolescent was obese, and the two EXT2+ adolescents eventually met the clinical criteria for lupus (4, 9 years post-biopsy). Co-morbidities among the remaining 24 patients included remote hepatitis B (2), Down's syndrome, lysinuric protein intolerance, recurrent UTIs, hypothyroidism, pregnancy (3), and obesity (2). Follow-up data was available for 12 children and 16 adolescents. Of the 12 children, 6 achieved complete remission, 4 achieved partial remission, and 2 had no response to treatment (1 transplant). Of the 16 adolescents, 4 achieved complete remission, 4 achieved partial remission, and 8 had no response to treatment (3 transplants). A child with "full-house" immunofluorescence staining achieved spontaneous disease remission.

conclusionOur non-lupus membranous nephropathy cohort represents one of the largest pediatric studies to date. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Diabetes Mellitus, Type 2Glomerulonephritis, MembranousHepatitis BAdolescentAutoantibodiesAutoantigensChildHumansImmunoglobulin GObesityReceptors, Phospholipase A2Young AdultAutoantibodiesAutoantigensImmunoglobulin GReceptors, Phospholipase A2Kidney biopsyMembranous nephropathyNephrotic syndromePediatrics

Identifiers

PMID35333973
OpenAlexW4220791563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.