Evidence map›Paper›PMID 35333945›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2022

Comparisons of the risk of myopericarditis between COVID-19 patients and individuals receiving COVID-19 vaccines: a population-based study.

Oscar Hou In Chou, Jiandong Zhou, Teddy Tai Loy Lee, Thompson Kot, Sharen Lee, Abraham Ka Chung Wai, Wing Tak Wong, Qingpeng Zhang, Shuk Han Cheng, Tong Liu and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. COVID-19 vaccine induced myocarditis in young males: A systematic review.European journal of clinical investigation · 2023
    Pooled it
  3. COVID-19 vaccination and carditis in children and adolescents: a systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2022
    Pooled it
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  11. COVID-19, Myocarditis and Pericarditis.Circulation research · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Oscar Hou In ChouDivision of Clinical Pharmacology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0001-7058-4708
Jiandong ZhouNuffield Department of Medicine, University of Oxford, Oxford, UK.
Teddy Tai Loy LeeDepartment of Emergency Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China.
Thompson KotDepartment of Anaesthesia, Princess Margaret Hospital, Hong Kong, China.
Sharen LeeEpidemiology Research Unit, Cardiovascular Analytics Group, Hong Kong, China.
Abraham Ka Chung WaiDepartment of Emergency Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China.
Wing Tak WongSchool of Life Sciences, Chinese University of Hong Kong, Hong Kong, China.
Qingpeng ZhangSchool of Data Science, City University of Hong Kong, Hong Kong, China.
Shuk Han ChengDepartment of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong, China.
Tong LiuTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Vassilios S VassiliouDepartment of Cardiology, Norwich Medical School, University of East Anglia, Norfolk, UK. v.vassiliou@uea.ac.uk.
Bernard Man Yung CheungDivision of Clinical Pharmacology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China. mycheung@hku.hk.
Gary TseDivision of Clinical Pharmacology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China. garytse86@gmail.com.
Chinese University of Hong Kong · HKCity University of Hong Kong · HKMedway School of Pharmacy · GBSecond Hospital of Tianjin Medical University · CNUniversity of East Anglia · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBoth COVID-19 infection and COVID-19 vaccines have been associated with the development of myopericarditis. The objective of this study is to (1) analyse the rates of myopericarditis after COVID-19 infection and COVID-19 vaccination in Hong Kong, (2) compared to the background rates, and (3) compare the rates of myopericarditis after COVID-19 vaccination to those reported in other countries.

methodsThis was a population-based cohort study from Hong Kong, China. Patients with positive RT-PCR test for COVID-19 between 1st January 2020 and 30th June 2021 or individuals who received COVID-19 vaccination until 31st August were included. The main exposures were COVID-19 positivity or COVID-19 vaccination. The primary outcome was myopericarditis.

resultsThis study included 11,441 COVID-19 patients from Hong Kong, four of whom suffered from myopericarditis (rate per million: 326; 95% confidence interval [CI] 127-838). The rate was higher than the pre-COVID-19 background rate in 2019 (rate per million: 5.5, 95% CI 4.1-7.4) with a rate ratio of 55.0 (95% CI 21.4-141). Compared to the background rate, the rate of myopericarditis among vaccinated subjects in Hong Kong was similar (rate per million: 5.5; 95% CI 4.1-7.4) with a rate ratio of 0.93 (95% CI 0.69-1.26). The rates of myocarditis after vaccination in Hong Kong were comparable to those vaccinated in the United States, Israel, and the United Kingdom.

conclusionsCOVID-19 infection was associated with significantly higher rate of myopericarditis compared to the vaccine-associated myopericarditis.

Indexed as

COVID-19COVID-19 VaccinesMyocarditisPericarditisCohort StudiesHumansUnited StatesCOVID-19 VaccinesCOVID-19MyocarditisMyopericarditisPericarditisVaccine

Identifiers

PMID35333945
PMCPMC8951670
OpenAlexW4225359655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.