Evidence map›Paper›PMID 35333692›Full record

ArticleEmerging microbes & infections2022

Immune durability and protection against SARS-CoV-2 re-infection in Syrian hamsters.

C J Field, T A Heinly, D R Patel, D G Sim, E Luley, S L Gupta, T H Vanderford, J Wrammert, T C Sutton

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

C J FieldDepartment of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, USA.
T A HeinlyDepartment of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, USA.
D R PatelDepartment of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, USA.
D G SimThe Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, USA.
E LuleyAnimal Diagnostic Lab, The Pennsylvania State University, University Park, PA, USA.
S L GuptaDepartment of Pediatrics, Division of Infectious Disease, School of Medicine, Emory University, Atlanta, GA, USA.
T H VanderfordDivision of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
J WrammertEmory-UGA Center of Excellence of Influenza Research and Surveillance (CEIRS), University Park, PA, USA.
T C SuttonDepartment of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, USA.

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
NIAID NIH HHS HHSN272201400004CNIH HHS P51 OD011132
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a pandemic. As immunity to endemic human coronaviruses (i.e. NL63 or OC43) wanes leading to re-infection, it was unknown if SARS-CoV-2 immunity would also decline permitting repeat infections. Recent case reports confirm previously infected individuals can become re-infected; however, re-infection may be due to heterogeneity in the initial infection or the host immune response, or may be the result of infection with a variant strain that escapes pre-existing immunity. To control these variables, we utilized the Syrian hamster model to evaluate the duration of immunity and susceptibility to re-infection with SARS-CoV-2. Hamsters were given a primary mock or SARS-CoV-2 infection (culture media or 10

Indexed as

COVID-19AnimalsAntibodies, NeutralizingAntibodies, ViralCricetinaeMesocricetusReinfectionSARS-CoV-2Antibodies, NeutralizingAntibodies, Viralantibodieshamsterimmunityre-infectionSARS-CoV-2

Identifiers

PMID35333692
PMCPMC9037228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.