ArticlePaediatric and perinatal epidemiology2022
Bone mineral density in very low birthweight adults-A sibling study.
Article in Paediatric and perinatal epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Pooled it
- Long term endocrine issues in adults born prematurely: a systematic review.Frontiers in pediatrics · 2025Pooled it
- Are birth characteristics related to bone quality measures in young adults? The HUNT study, Norway.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Blood and adipose tissue DNA methylation in adults born preterm with a very low birth weight - a sibling comparison study.Epigenomics · 2026Article
- Longitudinal course of bone health from infancy to mid-adulthood in preterm and term-born individuals.Scientific reports · 2025Article
- Birth Characteristics and Bone Mineral Density and Content in Young Adults: The HUNT Study, Norway.Calcified tissue international · 2025Article
- The Long-Term Impact of Preterm Birth on Metabolic Bone Profile and Bone Mineral Density in Childhood.Metabolites · 2025Article
- Psychological and Physical Health of a Preterm Birth Cohort at Age 35 Years.JAMA network open · 2025Article
- Comparative evaluation of bone mineral density in premature birth and low birth weight children by fractal analysis on panoramic radiographs.BMC oral health · 2025Article
- Preterm birth and risk of bone fractures during childhood and early adulthood.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Body Composition in Adults Born at Very Low Birthweight-A Sibling Study.Paediatric and perinatal epidemiology · 2025Article
- Cardiometabolic health in adults born with very low birth weight-a sibling study.Pediatric research · 2024Article
- Quantifying Bone Strength Deficits in Young Adults Born Extremely Preterm or Extremely Low Birth Weight.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Association of theInternational journal of molecular sciences · 2022Article
- Bone mineral density in very low birthweight adults-A sibling study.Paediatric and perinatal epidemiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren and adults born very low birthweight (VLBW, <1500 g) at preterm gestations have lower bone mineral density (BMD) and/or bone mineral content (BMC) than those born at term, but causality remains unknown.
objectivesOur aim was to assess BMD and BMC in adults born at VLBW in a sibling comparison setting to account for shared genetic and environmental confounders.
methodsWe conducted a cohort study of 77 adults born VLBW and 70 same-sex term-born siblings at mean age of 29 years. The primary outcome variables were BMD Z-scores, and BMC, of the femoral neck, lumbar spine, and whole body, measured using dual-energy X-ray absorptiometry. We analysed data by linear mixed models.
resultsThe VLBW adults had a 0.25 (95% CI 0.02, 0.47) Z-score unit lower femoral neck BMD, and 0.35 (95% CI 0.16, 0.54) grams lower femoral neck BMC than their term-born siblings, after adjustment for sex, age, and maternal smoking. Additional adjustment for adult body size attenuated the results. Lumbar spine, and whole body BMC were also lower in the VLBW group.
conclusionsIndividuals born at VLBW had lower BMC values at all three measurement sites, as well as lower femoral neck BMD Z-scores, compared to term-born siblings, partly explained by their smaller adult body size, but the differences were smaller than those reported previously with unrelated controls. This suggests that genetic or environmental confounders explain partly, but not exclusively, the association between preterm VLBW birth and adult bone mineralisation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.