ArticleBrain : a journal of neurology2022
Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy.
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30 citing papers in PubMed, 3 citations in OpenAlex.
- Explainable Deep Learning for MRI-Negative Temporal Lobe Epilepsy: Classification and Brain Region Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Neuroinflammation promotes the development of pharmacoresistant epilepsy by triggering the MSK1/CREB signaling pathway.Scientific reports · 2026Article
- Structural brain imaging biomarkers for predicting seizure recurrence after a first unprovoked seizure.Epilepsia open · 2026Article
- Morphometric Similarity Loss and Gray Matter Atrophy Align with Neurotransmitter and Mitochondrial Maps in Drug-Resistant Epilepsy.Neuropsychiatric disease and treatment · 2026Article
- Abnormal cortical topographic patterns associated with auditory verbal hallucination in first-episode schizophrenia.Translational psychiatry · 2025Article
- Analysis of brain volume in hippocampal sclerotic temporal lobe epilepsy using automatic brain segmentation technology.Quantitative imaging in medicine and surgery · 2025Article
- Morphometrics of the preserved post-surgical hemisphere in pediatric drug-resistant epilepsy and implications for post-operative cognition.bioRxiv : the preprint server for biology · 2025Article
- Vestibular-Dependent Functions Following MRgLITT-A Single-Group Longitudinal Study.Brain sciences · 2025Article
- Detection challenges of temporal encephaloceles in epilepsy: A retrospective analysis.Magnetic resonance imaging · 2025Review
- Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations.Frontiers in neuroscience · 2025Article
- Lobectomy vs. MRgLITT in Temporal Lobe Epilepsy (TLE): A Pilot Study Investigating Vestibulo-Spatial Functions.Journal of clinical medicine · 2024Article
- Lateralizing Value of Artificial Intelligence-Based Segmentation Software in MRI-Negative Focal Epilepsy.Journal of epilepsy research · 2024Article
- Differential reorganization of episodic and semantic memory systems in epilepsy-related mesiotemporal pathology.Brain : a journal of neurology · 2024Article
- Artificial intelligence in neurology: opportunities, challenges, and policy implications.Journal of neurology · 2024Review
- A WORLDWIDE ENIGMA STUDY ON EPILEPSY-RELATED GRAY AND WHITE MATTER COMPROMISE ACROSS THE ADULT LIFESPAN.bioRxiv : the preprint server for biology · 2024Article
- Macroscale intrinsic dynamics are associated with microcircuit function in focal and generalized epilepsies.Communications biology · 2024Article
- The role of the amygdala in ictal central apnea: insights from brain MRI morphometry.Annals of clinical and translational neurology · 2024Article
- Comparison of different group-level templates in gradient-based multimodal connectivity analysis.Network neuroscience (Cambridge, Mass.) · 2024Article
- Cerebellar white and gray matter abnormalities in temporal lobe epilepsy: a voxel-based morphometry study.Frontiers in neuroscience · 2024Article
- Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy.Network neuroscience (Cambridge, Mass.) · 2024Article
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Authors and funding
87 authors at 20 institutions in 18 countries.
Bo-Yong ParkMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID 0000-0001-7096-337X
Sara LarivièreMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID 0000-0001-5701-1307
Raul Rodríguez-CrucesMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Jessica RoyerMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Shahin TavakolMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Yezhou WangMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Lorenzo CaciagliDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Maria Eugenia CaligiuriNeuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.
Antonio GambardellaNeuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.ORCID 0000-0001-7384-3074
Luis ConchaInstitute of Neurobiology, Universidad Nacional Autónoma de México, Querétaro, México.ORCID 0000-0002-7842-3869
Simon S KellerInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID 0000-0001-5247-9795
Fernando CendesDepartment of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Marina K M AlvimDepartment of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Clarissa YasudaDepartment of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Leonardo BonilhaDepartment of Neurology, Emory University, Atlanta, GA, USA.
Ezequiel GleichgerrchtDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0002-4212-4146
Niels K FockeDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0001-5486-6289
Barbara A K KreilkampDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Martin DominInstitute of Diagnostic Radiology and Neuroradiology, Functional Imaging Unit, University Medicine Greifswald, Greifswald, Germany.
Felix von PodewilsDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Soenke LangnerInstitute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Christian RummelSupport Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.
Michael RebsamenSupport Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.
Roland WiestSupport Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.
Pascal MartinDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Raviteja KotikalapudiDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Benjamin BenderDepartment of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Terence J O'BrienDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Meng LawDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Benjamin SinclairDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Lucy VivashDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Patrick KwanDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Patricia M DesmondDepartment of Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Charles B MalpasDepartments of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Elaine LuiDepartment of Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Saud AlhusainiDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Colin P DohertyDepartment of Neurology, St James' Hospital, Dublin, Ireland.
Gianpiero L CavalleriDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Norman DelantyDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Reetta KälviäinenEpilepsy Center, Neuro Center, Kuopio University Hospital, Member of the European Reference Network for Rare and Complex Epilepsies EpiCARE, Kuopio, Finland.
Graeme D JacksonFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, 3010, Australia.ORCID 0000-0002-7917-5326
Magdalena KowalczykFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, 3010, Australia.
Mario MascalchiNeuroradiology Research Program, Meyer Children Hospital of Florence, University of Florence, Florence, Italy.
Mira SemmelrochFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, 3010, Australia.
Rhys H ThomasTransitional and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Hamid Soltanian-ZadehControl and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran.ORCID 0000-0002-7302-6856
Esmaeil Davoodi-BojdDepartment of Neurology, Henry Ford Health System, Detroit, MI, USA.
Junsong ZhangDepartment of Artificial Intelligence, Xiamen University, Xiamen, China.
Matteo LengeChild Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Renzo GuerriniChild Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy.ORCID 0000-0002-7272-7079
Emanuele BartoliniUSL Centro Toscana, Neurology Unit, Nuovo Ospedale Santo Stefano, Prato, Italy.
Khalid HamandiCardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff, UK.
Sonya FoleyCardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff, UK.
Bernd WeberInstitute of Experimental Epileptology and Cognition Research, University Hospital Bonn, Bonn, Germany.
Chantal DepondtDepartment of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Julie AbsilDepartment of Radiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Sarah J A CarrDivision of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Eugenio AbelaDivision of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Mark P RichardsonDivision of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.ORCID 0000-0001-8925-3140
Orrin DevinskyDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.
Mariasavina SeverinoIRCCS Istituto Giannina Gaslini, Genova, Italy.ORCID 0000-0003-4730-5322
Pasquale StrianoIRCCS Istituto Giannina Gaslini, Genova, Italy.
Costanza ParodiIRCCS Istituto Giannina Gaslini, Genova, Italy.
Domenico TortoraIRCCS Istituto Giannina Gaslini, Genova, Italy.
Sean N HattonDepartment of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-9149-8726
Sjoerd B VosDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
John S DuncanDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0002-1373-0681
Marian GalovicDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Christopher D WhelanDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Núria BargallóMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Jose ParienteMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Estefania Conde-BlancoEpilepsy Unit, Department of Neurology, Hospital Clínic, Barcelona, Spain.
Anna Elisabetta VaudanoNeurology Unit, Azienda Ospedaliero-Universitaria of Modena, OCB Hospital, Modena, Italy.
Manuela TondelliNeurology Unit, Azienda Ospedaliero-Universitaria of Modena, OCB Hospital, Modena, Italy.
Stefano MelettiNeurology Unit, Azienda Ospedaliero-Universitaria of Modena, OCB Hospital, Modena, Italy.ORCID 0000-0003-0334-539X
Xiang-Zhen KongLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Clyde FrancksLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Simon E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Benoit CaldairouNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Mina RytenDepartment of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, UK.
Angelo LabateNeurology, BIOMORF Department, University of Messina, Messina, Italy.ORCID 0000-0002-8827-7324
Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Paul M ThompsonImaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging and Informatics, USC Keck School of Medicine, Los Angeles, CA, USA.
Carrie R McDonaldDepartment of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.
Andrea BernasconiNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID 0000-0001-9358-5703
Neda BernasconiNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Boris C BernhardtMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID 0000-0001-9256-6041
Montreal Neurological Institute and Hospital · CAThe Royal Melbourne Hospital · AUIstituto Giannina Gaslini · ITNational Hospital for Neurology and Neurosurgery · GBRoyal College of Surgeons in Ireland · IEKing's College London · GBMeyer Children's Hospital · ITThe University of Melbourne · AUUniversidade Estadual de Campinas (UNICAMP) · BRUniversitätsmedizin Greifswald · DEUniversity of Modena and Reggio Emilia · ITHenry Ford Health System · USHertie Institute for Clinical Brain Research · DEHospital Clínic de Barcelona · ESMagna Graecia University · ITRadboud University Nijmegen · NLUniversitätsmedizin Göttingen · DEUniversité Libre de Bruxelles · BEUniversity of California San Diego · USCardiff University · GB
Funding
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7MLifespan Epilepsy Network Signatures (LENS): Leveraging ENIGMA-Epilepsy to Predict Cognitive Aging and Surgical OutcomesR01NS122827 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$3.8MPredicting Epilepsy Surgery Outcomes Using Neural Network ArchitectureR01NS110347 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BONILHA, LEONARDO F, DRANE, DANIEL L · 2019 to 2023
$3.6MPrediction of seizure lateralization and postoperative outcome through the use of deep learning applied to multi-site MRI/DTI data: An ENIGMA-Epilepsy studyR21NS107739 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONILHA, LEONARDO F, MCDONALD, CARRIE R · 2019 to 2019
$444kMedical Research Council MR/K013998/1Medical Research Council MR/N008324/1Medical Research Council MR/S00355X/1NIMH NIH HHS U54 MH091657NINDS NIH HHS R01 NS110347NINDS NIH HHS R01 NS122827NINDS NIH HHS R21 NS107739
Abstract
Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter structural alterations in temporal lobe epilepsy relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically investigated. Here, we addressed this gap using the multisite ENIGMA-Epilepsy dataset comprising MRI brain morphological measures in 732 temporal lobe epilepsy patients and 1418 healthy controls. We compared spatial distributions of grey matter asymmetry and atrophy in temporal lobe epilepsy, contextualized their topographies relative to spatial gradients in cortical microstructure and functional connectivity calculated using 207 healthy controls obtained from Human Connectome Project and an independent dataset containing 23 temporal lobe epilepsy patients and 53 healthy controls and examined clinical associations using machine learning. We identified a marked divergence in the spatial distribution of atypical inter-hemispheric asymmetry and regional atrophy mapping. The former revealed a temporo-limbic disease signature while the latter showed diffuse and bilateral patterns. Our findings were robust across individual sites and patients. Cortical atrophy was significantly correlated with disease duration and age at seizure onset, while degrees of asymmetry did not show a significant relationship to these clinical variables. Our findings highlight that the mapping of atypical inter-hemispheric asymmetry and regional atrophy tap into two complementary aspects of temporal lobe epilepsy-related pathology, with the former revealing primary substrates in ipsilateral limbic circuits and the latter capturing bilateral disease effects. These findings refine our notion of the neuropathology of temporal lobe epilepsy and may inform future discovery and validation of complementary MRI biomarkers in temporal lobe epilepsy.
Indexed as
ConnectomeEpilepsy, Temporal LobeAdultAtrophyHippocampusHumansMagnetic Resonance Imagingasymmetrycortical thicknessgradientsmulti-sitetemporal lobe epilepsy
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