Evidence map›Paper›PMID 35332957›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2023

Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies.

Daria Semeniak, Daniela F Cruz, Ashutosh Chilkoti, Maiken H Mikkelsen

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Review
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  10. Photonic Nanomaterials for Wearable Health Solutions.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daria SemeniakDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Daniela F CruzDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Ashutosh ChilkotiDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0002-1569-2228
Maiken H MikkelsenDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0002-0487-7585

Funding

Plasmonically Enhanced Point-of-care Detection of Cardiac Biomarkers by a Smart PhoneR01HL144928 · NHLBI · DUKE UNIVERSITY · PI MIKKELSEN, MAIKEN · 2019 to 2023
$3.4M
NHLBI NIH HHS R01 HL144928NIH HHS 5R01-HL144928-02
6 · The paper itself

Abstract

Fluorescence-based biosensors have widely been used in the life-sciences and biomedical applications due to their low limit of detection and a diverse selection of fluorophores that enable simultaneous measurements of multiple biomarkers. Recent research effort has been made to implement fluorescent biosensors into the exploding field of point-of-care testing (POCT), which uses cost-effective strategies for rapid and affordable diagnostic testing. However, fluorescence-based assays often suffer from their feeble signal at low analyte concentrations, which often requires sophisticated, costly, and bulky instrumentation to maintain high detection sensitivity. Metal- and metal oxide-based nanostructures offer a simple solution to increase the output signal from fluorescent biosensors due to the generation of high field enhancements close to a metal or metal oxide surface, which has been shown to improve the excitation rate, quantum yield, photostability, and radiation pattern of fluorophores. This article provides an overview of existing biosensors that employ various strategies for fluorescence enhancement via nanostructures and have demonstrated the potential for use as POCT. Biosensors using nanostructures such as planar substrates, freestanding nanoparticles, and metal-dielectric-metal nanocavities are discussed with an emphasis placed on technologies that have shown promise towards POCT applications without the need for centralized laboratories.

Indexed as

Biosensing TechniquesNanostructuresFluorescent DyesMetalsOxidesPoint-of-Care SystemsFluorescent DyesMetalsOxidesbiosensorsfluorescence enhancementmetal enhanced fluorescenceplasmonicspoint-of-care testing

Identifiers

PMID35332957
PMCPMC9986847

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.