ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2022
Radiologically isolated aquaporin-4 antibody neuromyelitis optica spectrum disorder.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Aquaporin-4-IgG positive radiologically isolated neuromyelitis optica spectrum disorder: treat or observe?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- The Different Immune Response Between Onset and Remission of AQP4 Antibody-Positive Optic Neuritis Based on RNA Sequencing of Whole Blood.Journal of inflammation research · 2025Article
- Is there a prodrome to NMOSD? An investigation of neurologic symptoms preceding the first NMOSD attack.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Investigation of health care use and a possible prodrome before the first attack in NMOSD and MOGAD.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Radiologically isolated syndrome and the possibility of preclinical disease activity in aquaporin-4 antibody NMOSD.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
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7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aquaporin-4 antibody (AQP4-Ab) Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare neuroinflammatory syndrome presenting predominantly with optic neuritis and transverse myelitis. We report a case of radiologically isolated longitudinally extensive optic neuritis in an asymptomatic 12-year-old female with positive serum AQP4-Ab, with resolution of imaging changes after immune therapy. By contrast to patients with radiologically isolated syndrome, of which some will never convert to multiple sclerosis, the pathogenicity of AQP4-Ab in the context of sub-clinical disease, supported treatment in our patient. Given the severe morbidity in AQP4-Ab NMOSD, prognostic biomarkers for disease severity are required to guide optimal therapy for patients.
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Registered trials
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