ArticleInternational endodontic journal2022
Endodontic pulp revitalization in traumatized necrotic immature permanent incisors: Early failures and long-term outcomes-A longitudinal cohort study.
Article in International endodontic journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Microbial Loads in Traumatized Immature Teeth and Their Impact on the Treatment Outcomes of Regenerative Endodontic Treatment: A Randomized Clinical Trial Comparing Chlorhexidine and Calcium Hydroxide.Dental traumatology : official publication of International Association for Dental Traumatology · 2025Trial
- Distinct Microbiota and Functional Pathway Profiles Define Success and Failure in Regenerative Endodontic Treatment.International endodontic journal · 2026Observational
- Radiographic Changes Following Regenerative Endodontic Treatment in Immature Permanent Teeth with Traumatic or Carious Pulp Necrosis: A Retrospective Study.Journal of functional biomaterials · 2026Article
- Tissue characteristics in a traumatised immature necrotic incisor after unsuccessful regenerative endodontic treatment: an immunohistological case report.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Decellularized Dental Pulp Matrix Hydrogel Promotes Functional Endodontic Regeneration In Situ.International endodontic journal · 2026Article
- Root-like apical hard-tissue structure associated with apical periodontitis in an immature permanent tooth: a case report and literature review.BMC oral health · 2026Review
- Treatment outcomes and prognostic factors of regenerative endodontic procedures in immature permanent teeth.BMC oral health · 2026Observational
- Frequency and associated factors of segmental root developmental arrest in endodontically treated immature permanent teeth with apical periodontitis: a retrospective cohort study.BMC oral health · 2026Article
- Favorable Eruption Despite External Replacement Root Resorption in Delayed Replantation of Avulsed Teeth Treated With Regenerative Endodontics-An Observational Study.Dental traumatology : official publication of International Association for Dental Traumatology · 2026Observational
- Assessment of volumetric changes after regenerative endodontic procedures using semiautomated and 3D U-NET automated CBCT segmentation: a retrospective cohort study.BMC oral health · 2025Article
- Article
- Machine learning models for prognosis prediction in regenerative endodontic procedures.BMC oral health · 2025Article
- Root development of immature necrotic permanent teeth following regenerative endodontic process: Case series.Dental research journal · 2025Article
- Artificial Intelligence in Dentistry: A Descriptive Review.Bioengineering (Basel, Switzerland) · 2024Review
- Pulp regeneration treatment using different bioactive materials in permanent teeth of pediatric subjects.Journal of conservative dentistry and endodontics · 2024Review
- Microbiological assessment of success and failure in pulp revitalization: a randomized clinical trial using calcium hydroxide and chlorhexidine gluconate in traumatized immature necrotic teeth.Journal of oral microbiology · 2024Article
- 3D finite element analysis of stress distribution as a result of oblique and horizontal forces after regenerative endodontic treatment part II: comparison of material thickness.BMC oral health · 2023Article
- Evaluation of removal efficiency of capping materials used in pulp revascularization in vitro.BMC oral health · 2023Article
- Evaluating the efficacy of endodontic microsurgery for teeth with an undeveloped root apex and periapical periodontitis after nonsurgical treatment failure.BMC oral health · 2023Article
- Is Revascularization the Treatment of Choice for Traumatized Necrotic Immature Teeth? A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
aimThis prospective cohort study evaluates clinical and radiographical outcomes of endodontic pulp revitalization (PR) of traumatized necrotic incisors. METHODOLOGY: Pulp revitalization was performed in 75 traumatized necrotic immature incisors from 71 patients. The radiographic outcome measures were continued root formation (width and length), root resorption, apex closure, periapical index, and root development stage. The clinical outcome measures were percussion pain, palpation pain, pathological tooth mobility, swelling, sinus tract, ankylosis, crown discolouration, response to pulp sensitivity test, and subjective pain. Treatment outcomes were categorized as a success based on the absence of clinical symptoms and when radiographic evidence was present for apical healing and continued root development. The performed statistical tests were repeated measures anova, pairwise comparisons of interactions (t-test), McNemar's test, and linear regression model.
resultsIn 45 of 75 teeth (60%), PR was successful with the resolution of clinical and radiographic signs and continued root development. PR failed due to the absence of bleeding (n = 19) and persistent infection (n = 11). PR showed statistically significant increases in root length (11%), and dentinal wall thickness (30%), root maturation (pre-operative 3.38 [CI 1.88; 4.88]; post-operative 4.04, [CI 2.56; 5.52]) apical closure (71.4%), healing of pre-operative apical periodontitis (100%), and healing of pre-operative inflammatory root resorptions (100%). Three predictive variables for continued root maturation were identified - root development stage at entry (p = .0001, β 0.649), [CI 0.431; 0.867], trauma to the soft tissues (p = .026, β -0.012), [CI -0.0225; -0.015], and pre-operative dentinal wall thickness (p = .009, β -0.001); [CI -0.001; 0.0001].
conclusionsOur findings indicate that PR provides satisfactory clinical and radiographical outcomes in traumatized necrotic incisors. The failed cases were related to lack of bleeding and persistent infections, indicating that new techniques are needed to improve the predictability of PR.
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