Evidence map›Paper›PMID 35332294›Full record

ArticleNature nanotechnology2022

A transistor-like pH-sensitive nanodetergent for selective cancer therapy.

Mingdong Liu, Liangqi Huang, Weinan Zhang, Xiaochuan Wang, Yuanyuan Geng, Yuhao Zhang, Li Wang, Wenbin Zhang, Yun-Jiao Zhang, Shiyan Xiao and 3 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature nanotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
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  8. Novel Swelling-Lytic Cell Death Triggered by Cargo-Free Ionizable Lipid Nanoparticles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  9. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Mingdong Liu *School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, P. R. China.
Liangqi Huang *School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, P. R. China.
Weinan Zhang *School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, P. R. China.
Xiaochuan WangSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, P. R. China.ORCID http://orcid.org/0000-0002-0487-6080
Yuanyuan GengSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, P. R. China.
Yuhao ZhangSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, P. R. China.
Li WangDepartment of Polymer Science and Engineering, University of Science and Technology of China, Hefei, P. R. China.
Wenbin ZhangNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, P. R. China.
Yun-Jiao ZhangNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, P. R. China.
Shiyan XiaoDepartment of Polymer Science and Engineering, University of Science and Technology of China, Hefei, P. R. China. xiaosy@ustc.edu.cn.ORCID http://orcid.org/0000-0003-1159-1224
Yan BaoGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. China. baoy5@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-5072-9428
Menghua XiongSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, P. R. China. xiongmh@scut.edu.cn.ORCID http://orcid.org/0000-0003-0020-5965
Jun WangSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, P. R. China. mcjwang@scut.edu.cn.ORCID http://orcid.org/0000-0001-9957-9208

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma membrane rupture is a promising strategy for drug-resistant cancer treatment, but its application is limited by the low tumour selectivity of membranolytic molecules. Here we report the design of 'proton transistor' nanodetergents that can convert the subtle pH perturbation signals of tumour tissues into sharp transition signals of membranolytic activity for selective cancer therapy. Our top-performing 'proton transistor' nanodetergent, P(C6-Bn

Indexed as

NanoparticlesNeoplasmsAnimalsHydrogen-Ion ConcentrationMicePolyethylene GlycolsProtonsPolyethylene GlycolsProtons

Identifiers

PMID35332294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.