ArticleNature2022
Design of protein-binding proteins from the target structure alone.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 305 papers.
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305citing papers in PubMed
42.5field-weighted citation impact, top 1% of its field
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Who cites it
305 citing papers in PubMed, 534 citations in OpenAlex.
- Global analysis of thermal and chemical denaturation using CheMelt: Thermodynamic dissection of highly thermostable de novo designed proteins.Protein science : a publication of the Protein Society · 2026Article
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- Deep learning-driven de novo discovery of binders targeting the transmembrane domain of BamA.Archives of microbiology · 2026Article
- Latent generative search unlocks de novo design of untapped biomolecular interactions at scale.bioRxiv : the preprint server for biology · 2026Article
- Ubiquitin receptor-mediated, ubiquitin-independent targeted protein degradation via 26Science advances · 2026Article
- Computational design of potent, broadly neutralizing anti-Nipah virus and Hendra virus miniproteins.bioRxiv : the preprint server for biology · 2026Article
- Sequence and structural determinants of efficacious de novo chimaeric antigen receptors.Nature biomedical engineering · 2026Article
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- AVIDbase: A biologically accurate structural dataset of nanobody-antigen complexes.Protein science : a publication of the Protein Society · 2026Article
- Engineered Protein-Based Ionic Conductors for Sustainable Energy Storage Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- CA-IV-directed small-molecule shuttle enables targeted brain delivery of biologics.Nature chemical biology · 2026Article
- Accelerating protein design by scaling experimental characterization.Nature communications · 2026Article
- AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins.Nature communications · 2026Article
- Intracellular protein binders for imaging, control and future therapeutics.Nature biomedical engineering · 2026Review
- De Novo-Designed Bifunctional Proteins for Targeted Protein Degradation.Journal of the American Chemical Society · 2026Article
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- Unraveling competitive protein interactions: A critical step toward improved production and therapeutics.Journal of advanced research · 2026Review
245 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
35 authors at 8 institutions in 2 countries.
Longxing Cao *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Brian Coventry *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Inna GoreshnikDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Buwei HuangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
William ShefflerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Joon Sung ParkDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-1575-1849
Kevin M JudeHoward Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3675-5136
Iva MarkovićVIB-UGent Center for Inflammation Research, Ghent, Belgium.
Rameshwar U KadamDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Koen H G VerschuerenVIB-UGent Center for Inflammation Research, Ghent, Belgium.
Kenneth VerstraeteVIB-UGent Center for Inflammation Research, Ghent, Belgium.
Scott Thomas Russell WalshChemical Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Nathaniel BennettDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Ashish PhalDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8405-4150
Aerin YangHoward Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8704-0288
Lisa KozodoyDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Michelle DeWittDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Lora PictonHoward Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0482-5187
Lauren MillerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Eva-Maria StrauchDeptartment of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0001-7382-747X
Nicholas D DeBouverUCB Pharma, Bainbridge Island, WA, USA.ORCID http://orcid.org/0000-0003-2545-6007
Allison PiresSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, USA.
Asim K BeraDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9473-2912
Samer HalabiyaDepartment of Electrical and Computer Engineering, University of Washington, Seattle, WA, USA.
Bradley HammersonSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, USA.
Wei YangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Steffen BernardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Lance StewartDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4264-5125
Ian A WilsonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6469-2419
Hannele Ruohola-BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5588-4531
Joseph SchlessingerDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5085-5969
Sangwon LeeDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Savvas N SavvidesVIB-UGent Center for Inflammation Research, Ghent, Belgium.ORCID http://orcid.org/0000-0003-3420-5947
K Christopher GarciaHoward Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9273-0278
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID http://orcid.org/0000-0001-7896-6217
University of Washington · USHoward Hughes Medical Institute · USGhent University · BECenter for Infectious Disease Research · USScripps Research Institute · USYale University · USNational Institutes of Health · USUniversity of Georgia · US
Funding
User Training & OutreachP30GM138396 · NIGMS · UCHICAGO ARGONNE, LLC · PI JANET L. SMITH · 2020 to 2026
$34.3MUser Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2MX-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6MStructure, function and engineering of immune cytokine receptor signalingR37AI051321 · NIAID · STANFORD UNIVERSITY · PI GARCIA, KENAN CHRISTOPHER · 2013 to 2022
$4.2MHigh-throughput assays and small-molecule discovery of antiviral candidates targeting influenza hemagglutininR01AI150885 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Seiya Kitamura, IAN A WILSON · 2021 to 2026
$3.6MChemical genetics of M. tuberculosis DosRST signaling and persistenceR01AI150855 · NIAID · MICHIGAN STATE UNIVERSITY · PI ABRAMOVITCH, ROBERT B · 2020 to 2024
$3.2MDesigned Vehicles for Blood Brain Barrier TraversalR01AG063845 · NIA · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.5MHigh-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0MPixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0MDesign of Antivirals and Immunogens Targeting ParamyxovirusesR01AI140245 · NIAID · WASHINGTON UNIVERSITY · PI STRAUCH, EVA-MARIA · 2018 to 2023
$1.9MHoward Hughes Medical InstituteNIAID NIH HHS HHSN272201700059CNIAID NIH HHS R01 AI140245NIAID NIH HHS R01 AI150855NIAID NIH HHS R01 AI150885NIAID NIH HHS R37 AI051321NIA NIH HHS R01 AG063845NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM138396NIGMS NIH HHS P41 GM103393NIH HHS S10 OD012289NIH HHS S10 OD021527
Abstract
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge
Indexed as
Carrier ProteinsProteinsAmino AcidsBinding SitesProtein BindingAmino AcidsCarrier ProteinsProteins
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.